The Efficacy of Heparin-boned Viabahn Endoprosthesis and Paclitaxel-coated Balloons for Complex Femoropopliteal Lesions

Inclusion Criteria: 1. The patient presented a score from 2 to 5 following Rutherford classification. 2. The patient is willing to comply with specified follow-up evaluations at the specified times. 3. The patient is ≥ 18 years old. 4. Patient understands the nature of the procedure and provides written informed consent before enrolment in the study 5. The patient has a projected life expectancy of at least 24 months 6. Before enrolment, the guidewire has crossed the target lesion 7. Subject has a de novo or restenotic lesion with ≥ 70% stenosis in femoropopliteal artery, and for de novo lesion, the total lesion length ≥ 25cm, or chronic total occlusion (CTO) length ≥15cm. 8. There is angiographic evidence of patent infrageniculate popliteal artery and at least one distal runoff to the foot. 9. Origin and proximal 1 cm of Superficial Femoral Artery (SFA) are patent. 10. Reference vessel diameter (RVD) ≥ 4 mm by visual estimation. Exclusion Criteria: 1. Previous bypass surgery or stenting in the target vessel 2. Patients who exhibit acute intraluminal thrombus at the target lesion vessel 3. Patients with known hypersensitivity or contraindication to any of the following medications: Nitinol-titanium, antiplatelet therapy, anticoagulants, or thrombolytics therapy 4. Pregnant women or Female patients with potential childbearing 5. Use of thrombectomy, atherectomy, or laser devices during the procedure 6. Untreated inflow disease of the ipsilateral pelvic arteries (more than 50% stenosis or occlusion) 7. The patient is currently participating in another investigational drug or device study that interferes with the study 8. Significant renal dysfunction (Serum creatinine \>3.0mg/dl) 9. Patient with Known allergy to contrast media 10. Significant gastrointestinal bleeding or any coagulopathy that would contraindicate the use of anti-platelet therapy. 11. Femoral or popliteal aneurysm. 12. Current peritoneal or hemodialysis.