Application of Early Bundle Management of Mechanical Ventilation to Prevent Ventilator Dependence in Children

Children's Hospital of Fudan University150 enrolled

Overview

This study is based on the risk factors of previous studies to formulate a bundle treatment plan to prevent ventilator dependence in children, in order to reduce the proportion of ventilator dependence in children and provide a theoretical basis for reasonable intervention of children with mechanical ventilation. Participants will receive intensive rehabilitation, nutrition, and tracheotomy at different time periods. Researchers will compare the control group to see whether it can reduce the incidence of ventilator dependence

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

150

Conditions

Prolonged Mechanical Ventilation

Interventions

early bedside rehabilitation

① electrical diaphragm stimulation, ② electrical muscle stimulation, ③ passive limb movement, ④ respiratory rehabilitation.

nutrition programDIETARY_SUPPLEMENT

(1) nutrition department consultation, (2) MDT to develop individualized nutritional pathways, nutrient formulations and use methods, and achieve the target nutritional level within 2 weeks

tracheotomyPROCEDURE

early tracheotomy for special diseases (e.g central nervous system diseases) receiving mechanical ventilation 14-21 days recommended tracheotomy

Eligibility

Sex: ALLMin age: 28 DaysMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: （1）All stable children receiving mechanical ventilation （1）Stable condition: respiratory rate does not exceed 20% of the basic respiratory rate, PEEP\< 8. 60%, VIS score\< 20, there is no hypotension (70mmHg+ age ×2, 70mmHg under one year old), no higher than the P95 of the same sex and age Exclusion Criteria: 1. Status epilepticus 2. Active intracranial hemorrhage 3. Intracranial hypertension 4. Unstable fracture of the spine 5. Spinal cord injury 6. There are injuries that affect the implementation of rehabilitation 7. Acute surgery was performed on the same day. 8. Body temperature over 40℃ 9. Brain function failure

Locations (1)

Children's hospital of Fudan University

Shanghai, Shanghai Municipality, China

RECRUITING

Outcomes

Primary Outcomes

limb skeletal muscle function indexes

Skeletal muscle thickness and cross-sectional area were measured

Time frame: 21 days after enrollment

Data from ClinicalTrials.gov

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