This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
LMVOS is a prospective, real-world registry lasting for 22 years. A total of 8000 patients with large- or medium-vessel occlusion will be enrolled.
Study Type
OBSERVATIONAL
Enrollment
8,000
Visits at 90±7 days after stroke onset were conducted by trained and blinded investigators, with face-to-face, telephone call or Internet access.
Affiliated Hospital of Southwest Medical University
Luzhou, China
RECRUITINGmodified Rankin Scale (mRS) score
Ordinal distribution of mRS at 90±7 days; modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 1 no clinically significant disability, 2 slight disability, 3 moderate disability but remaining able to walk unassisted, 4 moderately severe disability, 5 severe disability, and 6 death)
Time frame: 90±7 days
Excellent functional outcome
Proportion of subjects with mRS 0-1 at 90±7 days.
Time frame: 90±7 days
Good functional outcome
Proportion of subjects with mRS 0-2 at 90±7 days.
Time frame: 90±7 days
mRS 0-3
Proportion of subjects with mRS 0-3 at 90±7 days.
Time frame: 90±7 days
Change of National Institutes of Health Stroke Scale (NIHSS)
Change of National Institutes of Health Stroke Scale (NIHSS, a scale between 0 and 42 on which higher scores indicate more severe neurologic deficits) from baseline to 24 hours.
Time frame: 24 hours
Change of National Institutes of Health Stroke Scale (NIHSS)
Change of National Institutes of Health Stroke Scale (NIHSS, a scale between 0 and 42 on which higher scores indicate more severe neurologic deficits) from baseline to 7 days.
Time frame: 7 days
Symptom-to-thrombolysis time (STT)
Time from onset of symptoms to thrombolytic therapy.
Time frame: 24 hours
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Door-to-Needle Time
Time from the arrival of stroke patient in emergency to initiation of thrombolysis therapy.
Time frame: 24 hours
Door-to-Puncture Time (DPT)
ime from the arrival of stroke patient in emergency to groin puncture.
Time frame: 24 hours
Onset-to-recanalization time
Time from symptom onset to the beginning of recanalization (recanalization defined as expanded TICI scale≥2b).
Time frame: 24 hours
Door-to-Recanalization Time (DRT)
Time from the arrival of stroke patient in emergency to the beginning of recanalization (recanalization defined as expanded TICI scale≥2b).
Time frame: 24 hours
Puncture-to-recanalization time
Time from groin puncture to recanalization (recanalization defined as expanded TICI scale≥2b).
Time frame: 24 hours