The MICRO-SNAPE registry will collect data from patients undergoing investigation of microvascular dysfunction and coronary spasm in Europe and North America.
Microvascular dysfunction is an important determinant of patients´quality of life and prognosis, which however remains poorly classified. Given the high burden of disease and the severity of the functional impairment in these patients, the lack of a clear understanding and diagnosis has a potentially large clinical importance. It is therefore important to better describe the phenotype of these patients. The MICRO-SNAPE registry will allow investigating these associations. Patient data as collected during the local clinical practice and at the operator's discretion, will be retrospectively entered in this non-interventional registry in anonymous form.
Study Type
OBSERVATIONAL
Enrollment
1,000
Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and papaverin or adenosine, Resting distal coronary to aortic pressure ratio, resting flow ratio, fractional flow reserve, Coronary Flow Reserve and Microvascular resistance using the thermodilution method and acetylcholine.
Center of Cardiology, Cardiology I, university hospital Mainz
Mainz, Rhineland-Palatinate, Germany
RECRUITINGIdentification of endotypes of coronary vasomotor function
Patients will be classified in different endotypes according to the pattern of their responses to endothelium-dependent and independent vasodilators.
Time frame: immediately after the invasive measurement
Accuracy of clinical criteria for the diagnosis of microvascular and epicardial spasm
The clinical criteria commonly used for the diagnosis of spasm (based on ECG and angina) will be validated against the benchmark invasive measurements
Time frame: immediately after the invasive measurement
Normal values expressing endothelium-dependent coronary flow reserve
Acetylcholine-induced coronary flow reserve in subjects without microvascular dysfunction.
Time frame: immediately after the invasive measurement
Sex impact on coronary vasospasm measures
Difference between males and females in microvascular and epicardial spasm measures
Time frame: immediately after the invasive measurement
Coronary bridge and epicardial spasm
Impact of coronary brudge on the incidence of epicaridal spasm
Time frame: immediately after the invasive measurement
Acetylcholine versus adenosine responses
Comparison of adenosine- versus acetylcholin-induced microvascular dilatation (IMR)
Time frame: immediately after the invasive measurement
Normal values and associations of resting microvascular resistances
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We will assess the normal values of resting microvascular resistances using a frequentistic approach and study their associations with comorbidities and clinical parameters.
Time frame: Immediately upon measurment