CRISPR-Edited Allogeneic Anti-CLL-1 CAR-T Cell Therapy in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Inclusion Criteria: * Documented diagnosis of AML with either refractory or relapsed disease, * Non-proliferative disease * No more than 3 prior lines of therapy (induction, consolidation with or without allogeneic stem cell transplant, and maintenance are considered 1 line of therapy) * No available therapy with reasonable survival benefit * Eastern Cooperative Oncology Group (ECOG) performance status grade of 0 or 1 and fit for allogeneic stem cell transplant * Adequate renal, hepatic, pulmonary, and cardiac function, with specific laboratory criteria * Women of child-bearing potential and men with a female partner who has child-bearing potential must agree to use acceptable, effective methods of birth control. Exclusion Criteria: * Acute promyelocytic leukemia * Extra-medullary disease (EMD) that is metabolically inactive by 18-FDG PET-CT * Prior treatment with CAR-T cell therapy * Allogeneic stem cell transplant within 100 days before lymphodepletion * Active graft-vs-host disease requiring therapy * Known active or prior history of central nervous system involvement * Seropositive for or history of human immunodeficiency virus (HIV) * Vaccinated with live, attenuated vaccine within 4 weeks prior to lymphodepletion * Active hepatitis B or C infection * Primary immunodeficiency or autoimmune disease * Known life-threatening allergies, hypersensitivity, or intolerance to CB-012 or its excipients Other inclusion and exclusion criteria may apply.