ASA 81 mg vs 162 mg During Frozen Embryo Transfer (FET)

Clinique Ovo1,207 enrolled

Overview

The use of low dose aspirin is recommended for high risk patients to reduce the risk of pre-eclampsia, placental abruption and antepartum hemorrhage. Recent studies have shown that in a specific population, the use of low dose aspirin might reduce the risk of preterm birth in pregnant women with singleton pregnancy. In June 2022, clinique ovo started implementing the use of Aspirin 162 mg instead of 81 mg in the frozen embryo transfer cycles based on recent study outcomes. The use of Aspirin 162 mg might have additional benefits on the embryo transfer outcomes by decreasing the miscarriage. Moreover this can be continued until late in pregnancy without adverse effects.

Study Type

OBSERVATIONAL

Enrollment

1,207

Conditions

Fertility Disorders

Interventions

Frozen embryo transferOTHER

A frozen embryo transfer involves thawing a fertilized embryo and transferring it in the uterus in order to obtain a pregnancy

Eligibility

Sex: FEMALEMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women taking aspirin 81 mg or 162 mg prior to an autologous embryo transfer * Age \< 40 years old * Embryo transfer cycle done at clinique ovo Exclusion Criteria: * Egg or embryo recipient * History of recurrent miscarriages, defined as ≥ 3 consecutive losses * Patients that needed Viagra, PRP or other modalities to improve their endometrial thickness * Uterine factor infertility * Abnormal hormonal profiles * Stimulated embryo transfer cycles * History of recurrent implantation failure defined as failed ≥ 2 euploid embryos transfer or ≥ 3 blastocysts

Locations (1)

Clinique Ovo

Montreal, Quebec, Canada

Outcomes

Primary Outcomes

Compare clinical pregnancy rate between patients prescribed Aspirin 81 mg vs Aspirin 162 mg

clinical pregnancy is the presence of fetal heartbeat at the viability ultrasound

Time frame: Time Frame: 6 to 8 weeks after Frozen Embryo Transfer

Data from ClinicalTrials.gov

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