Bioindicators Associated With Sarcopenia Before and After Intensive Lifestyle Intervention

Lijun Yang99 enrolled

Overview

The goal of this clinical trial is to explore whether the bioindicators of body composition, nutrition-related indicators (lymphocytes, albumin), lipids, and thyroid hormones are associated with sarcopenia and the changes in these indicators after an intensive lifestyle intervention. The main questions it aims to answer are: * whether the bioindicators such as lymphocytes, albumin, lipids, thyroid hormones, fat mass, fat-free mass, and basal metabolic mass are associated with the development of sarcopenia. * the changes of these bioindicators that occur in older adults after going through an intensive intervention. Participants will receive a 3-month intensive intervention consisting of an intensive nutritional intervention and an individually designed exercise intervention. Nutritional and exercise prescriptions are co-designed through a nutritionist and rehabilitation physician. Researchers will compare bioindicators in the sarcopenia group before and after intensive lifestyle intervention to determine the association with sarcopenia.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Sarcopenia

Interventions

Intensive nutritional interventions were as follows: i）Estimation of ideal body weight according to height, calculation of calories by giving 30-40kcal/kg/day according to BMI stratification, and calculation of daily protein requirement at 1.5g/kg/day, which was finally converted into daily dietary recommendations according to the results of the calculations. ii）Distribution of additional protein supplementation by whey protein, each sachet containing 15g of whey protein. The resistance training program included 5 min of warm-up, 20 min of muscle strength training, and 5 min of slow walking and was performed three times a week. Resistance training involved a dumbbell and sandbags as weights for the major muscles of the upper and lower limbs. In the study, aerobic training is brisk walking or jogging for 30 minutes/day, five times a week.

Eligibility

Sex: ALLMin age: 65 YearsMax age: 90 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 1\) Resident elderly aged 65-90 years old in the district. * 2\) Voluntary participation in the trial and signing the informed consent form. Exclusion Criteria: * 1\) People with systemic severe diseases, organ failure, malignant tumors, neuromuscular degenerative diseases, or active weight loss. * 2\) People with cognitive impairment, incapacitation, or severe mental illnesses who cannot cooperate with the test. * 3\) People with cardiac pacemakers and artificial joint implantation or others who cannot undergo the BIA test. * 4\) People with severe cardiorespiratory dysfunction and physical disabilities who cannot complete the exercise training. * 5\) Incomplete data, refusal to participate in the survey, body composition analysis, and blood collection.

Outcomes

Primary Outcomes

AMMI(appendicular muscle mass index)

Bioelectrical impedance analysis was used to obtain appendicular muscle mass (AMM) and height. The unit of AMM and height were represented as kilogram and meter respectively. AMMI were calculated as AMM/height\^2 (kg/m\^2).