The purpose of the study is to explore the effect of nature-based exposure on immunological biomarkers and the condition and symptoms of atopic skin. Our hypothesis is that regular exposure to nature-based, high biodiversity material on skin, strengthens the skin's protective barrier and has a positive effect on the immunological biomarkers associated with atopic dermatitis. Further our hypothesis is that the difference between the groups (active and placebo) is noticeable during winter time when the disease is typically worse because of the cold weather. The study aim at scientific publication and is double-blinded and placebo-controlled. Time of the intervention is 6-7 months: intervention starts before the Finnish winter time and ends before the summer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
142
Lotion is used at minimum three times per week and at least to arms. No restrictions to normal life and self-care. Atopy medicines and lotions are allowed when needed, only the usage amount is followed.
Lotion is used at minimum three times per week and at least to arms. No restrictions to normal life and self-care. Atopy medicines and lotions are allowed when needed, only the usage amount is followed.
Uute Scientific Oy
Helsinki, Finland
Transepidermal water loss (TEWL)
Transepidermal water loss level at designated places
Time frame: 4 or 7 months
POEM (Patient Oriented Eczema Measure)
POEM points during the study
Time frame: Assessment is done every two weeks by the participant
Need of atopy medicines
Number of medicine free days
Time frame: 4 or 7 months
EASI (Eczema Area and Severity Index)
EASI score
Time frame: 4 or 7 months
Erythema index
Erythema index at designated places
Time frame: 4 or 7 months
Skin pH value
Skin pH value of designated places
Time frame: 4 or 7 months
Immunological markers in saliva, skin and blood samples
Immunological markers, like cytokines, in saliva, skin and blood samples and their expression analyzed from RNA.
Time frame: 4 or 7 months
Adverse events
Adverse events during the trial
Time frame: Assessment is done every two weeks by the participant
NRS itch
NRS itch score during the trial
Time frame: Assessment is done every two weeks by the participant
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