Hand Function Impairment in Systemic Sclerosis: Outcomes, Mechanisms and Experience (HANDSOME)

UMC Utrecht300 enrolled

Overview

Almost 90% of systemic sclerosis (SSc) patients experience hand function limitation, which leads to impaired daily functioning and work participation. An important cause of impaired hand function are contractures of the hand, which are reported in up to a half of patients. With this longitudinal cohort study in patients with SSc and VEDOSS (very early diagnosis of systemic sclerosis) the investigators aim to gain more insight into processes involved in hand function impairment.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Systemic Sclerosis

Interventions

Imaging, blood samples, fuctional tests and physical examinationDIAGNOSTIC_TEST

Imaging, blood samples, fuctional tests and physical examination

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years Exclusion Criteria: * Patients with diabetic cheiroarthropathy and Dupuytren's disease, based on expert opinion

Locations (1)

UMC Utrecht

Utrecht, Netherlands

RECRUITING

Outcomes

Primary Outcomes

Determination of risk factors for hand function impairment in systemic sclerosis (SSc) patients with early disease, very early disease and established hand impairment (contractures) at 2 years follow-up

Time frame: 2 years

Secondary Outcomes

Identify underlying mechanisms

Time frame: 2 years

- Validation of the Dutch PASTUL questionnaire

Time frame: 2 years

Data from ClinicalTrials.gov

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