Mapping the Health Status of the Population of French Polynesia: the MATAEA Project

Prevalence of obesity

Proportion of participants with indicators of obesity based on physical measurements (BMI, waist circumference) and quantification of lipid levels from blood samples.

Time frame: 2 years

Prevalence of diabetes

Proportion of participants with indicators of diabetes based on self-reported data on diabetes history (previous diagnosis, antidiabetic treatment) and quantification of glycated haemoglobin from blood samples.

Time frame: 2 years

Prevalence of cardiovascular diseases

Proportion of participants with indicators of cardiovascular diseases based on self-reported data on history of hypertension (previous diagnosis, treatment for hypertension), blood pressure measurement, and quantification of lipid levels from blood samples.

Time frame: 2 years

Association between non-communicable diseases and behavioral factors

Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and behavioral factors such as tobacco smoking, alcohol consumption, diet or physical activity data self-reported by the participants in the questionnaire.

Time frame: 2 years

Association between non-communicable diseases and physical measurements

Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and physical measurements such as BMI (based on the BMI formula i.e., weight in kilograms divided by height in meters squared).

Time frame: 2 years

Association between non-communicable diseases and blood analyses

Calculation of odd ratios to investigate association between non-communicable diseases (obesity, diabetes, cardiovascular diseases) and blood analyses (such as glycated haemoglobin and lipid levels).

Time frame: 2 years

Seroprevalence of communicable diseases

Proportion of participants with IgG antibodies, detected in blood samples, specific for different pathogens : arboviruses (four dengue serotypes, Zika, chikungunya), hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…). Proportion of participants with positive filarial antigenemia to assess the prevalence of Bancroftian lymphatic filariasis.

Time frame: 2 years

Composition of microbiome

Bacterial DNA sequencing from stool and saliva samples to assess the gut and oral microbiota profiles and association with lifestyle behavior, diet and susceptibility to communicable and non-communicable diseases.

Time frame: 2 years

Level of exposure to heavy metals

Quantification of levels of heavy metals (including mercury and lead) from blood samples and association with lifestyle behavior and diet.

Time frame: 2 years

Level of exposure to pesticides

Quantification of levels of pesticides (including chlordane and toxaphene) from blood samples and association with lifestyle behavior and diet.

Time frame: 2 years

Level of exposure to mosquito bites

Proportion of participants with IgG antibodies targeting mosquito salivary proteins in blood samples to assess the risk of infection by mosquito-borne viruses

Time frame: 2 years

Prevalence of ciguatera poisoning

Estimation of the rate of ciguatera poisoning in the population based on data self-reported by the participants in the questionnaire e.g. the occurrence of symptoms suggestive for ciguatera poisoning at least once in their lifetime

Time frame: 2 years

Demographic and adaptive history of French Polynesians using genomics

Human Whole Genome Sequencing from saliva samples to reconstruct the genetic history of the population of French Polynesia, in terms of both demographic and adaptive history.

Time frame: 2 years

Genetic susceptibility to obesity

Genome-wide association studies to identify human genetic factors that are associated with BMI or lipids levels.

Time frame: 2 years

Genetic susceptibility to diabetes

Genome-wide association studies to identify human genetic factors that are associated with HbA1c.

Time frame: 2 years

Genetic susceptibility to communicable diseases

Genome-wide association studies to identify human genetic factors that are associated with the detection of IgG antibodies specific for different pathogens: arboviruses, hepatitis B and C viruses, hantaviruses, SARS-CoV-2 and other pathogens known to regularly cause infections in French Polynesia (including influenza viruses, human immunodeficiency virus…).

Time frame: 2 years