PeRioperative Immunotherapy Combined With Sacituzumab Govitecan in Muscle Invasive blAdder Cancer

Inclusion Criteria: 1. Willing and able to provide written informed consent. 2. Ability to comply with the study procedures and requirements and restrictions in this protocol. 3. Age ≥ 18 years. 4. Muscle invasive urothelial carcinoma stage cT2-T4cN0-1cM0. Patients with mixed histologies are required to have a dominant (i.e. 50% at least) urothelial carcinoma pattern. 5. Fit and planned for cystectomy (according to local guidelines). 6. Refusal of neoadjuvant cisplatin-based chemotherapy or patients in whom neoadjuvant cisplatin-based therapy is not appropriate. (This will be determined by the investigator and not solely based in Galsky Criteria). 7. Representative formalin-fixed paraffin-embedded (FFPE) tumor specimens (blocks preferred) or at least 15 unstained slides, with an associated pathology report, for testing at the study sponsor site. Patients with fewer than 15 unstained slides available at baseline (but no fewer than 10) may be eligible following discussion with the PI of the study. 8. Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2. 9. Adequate hematologic and end-organ function tests defined by the following: 1. White Blood Cell (WBC) ≥ 2.0x109/L, 2. Neutrophils ≥1.5x109/L, 3. Platelets ≥100 x109/L, 4. Hemoglobin ≥ 10 g/dL, 5. Creatinine clearance ≥ 30 mL/min as assessed by the Cockcroft-Gault equation 6. Aspartate aminotransferase (AST) ≤ 2.5 x upper limit of normal(ULN), 7. Alanine aminotransferase (ALT) ≤2.5 x ULN, 8. Bilirubin ≤1.5 X ULN. 10. Adequate coagulation (Prothrombin Time \[PT\]) or International Normalized Ratio \[INR\] and Activated Partial Thromboplastin Time \[aPTT\]) ≤ 1.5 x ULN unless subject is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants. 11. Negative pregnancy test within 3 days of Day 1 Cycle 1 for female patients of childbearing potential. 12. Male patients and female patients of childbearing potential who engage in heterosexual intercourse must agree to use protocol-specified method(s) of contraception. Exclusion Criteria: 1. Concurrent enrollment in another interventional clinical trial, unless in a follow-up period or it is an observational study. 2. Having received previous anticancer therapy including: 1. Any investigational anticancer therapy received within 28 days or 5 half-lives (whichever is longer) of first dose of study treatment. 2. Any previous intravenous chemotherapy specific for bladder cancer. 3. Previous systemic treatment with topoisomerase 1 inhibitors. 4. Prior Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) or Programmed death-1(PD-1)/ programmed death-ligand 1(PD-L)1-targeting immunotherapy. 5. Previous treatment with high dose chemotherapy and bone marrow transplant 6. Previous radiotherapy specific for bladder cancer 3. Underlying medical conditions that might make the administration of study drugs hazardous or that might obscure the interpretation of adverse events including: * 3.1 Known or suspected autoimmune disease. Patients with a history of inflammatory bowel disease (including Crohn's disease and ulcerative colitis) and autoimmune disorders such as rheumatoid arthritis, systemic progressive sclerosis (scleroderma), systemic lupus erythematosus or autoimmune vasculitis (e.g., Wegener's granulomatosis) are excluded from this study; Patients with other autoimmune disorders such as a history of Hashimoto's thyroiditis \[only requiring hormone replacement\], type I diabetes, psoriasis \[not requiring systemic treatment\], or conditions not expected to recur in the absence of an external trigger are allowed to participate. * 3.2 History of primary immunodeficiency. * 3.3 A positive tests for Hepatitis B surface antigen or Hepatitis C ribonucleic acid (RNA), active tuberculosis, or other active infection requiring therapy at the time of inclusion. HIV positive patients are allowed as far as they have the disease controlled according to their treating physicians based on lymphocyte counts and viral load. \- 3.4 Medical conditions requiring the use of immunosuppressive medications, with the exceptions of intranasal and inhaled corticosteroids or systemic corticosteroids at physiological doses not to exceed 10 mg/day of prednisone, or an equivalent corticosteroid. Steroids as premedication for hypersensitivity reactions (eg, CT scan premedication) will be allowed. 4. Patient receiving treatment with inhibitors or inducers of UGT1A1 at the time of enrollment. 5. Patient receiving treatment with high dose systemic corticosteroids (\>10 mg of prednisone or its equivalent) within 2 weeks of C1D1. 6. Patients who have received a vaccination within 30 days prior to inclusion (examples include, but are not limited to, intranasal influenza vaccines, typhoid \[oral\] vaccines, and Bacillus Calmette-Guerin \[BCG\]). Patients are allowed to receive the COVID-19 vaccine to reduce the risk and complications of COVID-19 infection. The study visits should continue as planned if vaccination occurs while the patient is on the study. 7. Malignancy, other than urothelial cancer, in the previous 2 years. Patients with low-risk prostate cancer (defined as Stage T1/T2a, Gleason score ≤ 6, and Prostatic specific antigen (PSA) ≤ 10 ng/mL) appropriately treated or that are treatment-naive and undergoing active surveillance are eligible. Also, noninvasive malignancies such as cervical carcinoma in situ, non-melanomatous carcinoma of the skin, or ductal carcinoma in situ of the breast, that have undergone potentially curative therapy are not excluded. 8. Major surgical procedure within 4 weeks prior to enrollment or anticipation of need for a major surgical procedure during the course of the study other than for diagnosis or treatment of its urothelial cancer. 9. Severe infection within 4 weeks prior to enrollment in the study including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia. 10. Met any of the following criteria for cardiac disease: 1. Myocardial infarction or unstable angina pectoris within 6 months of enrollment. 2. History of serious ventricular arrhythmia (ie, ventricular tachycardia or ventricular fibrillation), high-grade atrioventricular block, or other cardiac arrhythmias requiring antiarrhythmic medications (except for atrial fibrillation that is well controlled with antiarrhythmic medication). 3. History of QT interval prolongation. 11. Patient currently on dialysis. 12. Gastrointestinal perforation within 6 months of enrollment. 13. Patients who have organ allografts. 14. Other concurrent medical or psychiatric conditions that, in the Investigator's opinion, may be likely to confound study interpretation or prevent completion of study procedures and follow-up examinations. 15. Known allergy or hypersensitivity to study drugs formulations. 16. Patients who have invasive catheters that under the investigator criteria might put the patient at risk of developing severe complications due to neutropenia development. 17. Females who are pregnant, lactating, or intend to become pregnant during their participation in the study.