Postoperative pain after laparoscopic hepatectomy is composed of multiple factors, and the peak pain of postoperative pain mainly occurs within the first 24 hours, so it is particularly important to find an appropriate analgesic method. Transversus abdominis plane block (TAPB) and Rectus sheath blocks (RSB) are widely used in abdominal surgery, but too deep a needle tip during RSB may puncture abdominal organs. TAPB and RSB can only provide somatic analgesia, but lack visceral analgesia. Recently, Erector spinae plane block (ESPB) has been used in some studies for analgesia after abdominal surgery. The purpose of this study is to compare the analgesic effect and postoperative recovery effect of erector spinae plane block and transverse abdominis plane block combined with rectus sheath block in patients undergoing laparoscopic hepatectomy. Therefore, this study has important clinical implications.
In a double-blind randomized controlled study, researchers randomized 60 patients undergoing laparoscopic hepatectomy to TAPB combined with RSB or ESPB, with both groups receiving additional standardized treatment, including multimodal analgesia. The main outcome was the consumption of morphine within 24 hours after surgery. Secondary outcomes included the number of rescue analgesia at 1h, 2h, 4h, 8h and 24 hours after surgery, VAS scores in resting and coughing at 1h, 2h, 4h, 8h and 24h after surgery, CVP values at 5, 10, 15 and 30min after nerve block, QoR-15 patient questionnaire scores before and 24h after surgery, and postoperative liver function (the percentage increase of AST and ALT compare with preoperative), postoperative complications and discharge time.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
60
The experimental group received ultrasound-guided erector spinae plane block, and bilateral erector spinae plane block was performed at T7 segment with 20ml 0.375% ropivacaine on each side.While the control group received ultrasound-guided transversus abdominis plane block combined with rectus sheath block, which will be performed under the costal margin with 10ml 0.375% ropivacaine for bilateral transversus abdominis plane block and 10ml 0.375% ropivacaine for bilateral rectus sheath block.
Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology
Wuhan, Hubei, China
The dose of morphine used
dosage of analgesic pump
Time frame: 24 hours after surgery
The dose of morphine used
dosage of analgesic pump
Time frame: 1hour, 2hours, 4hours and 8hours after surgery
The number of rescue analgesia
times of rescue analgesia
Time frame: 1hour, 2hours, 4hours, 8hours and 24hours after surgery
Visual analogue scale scores in resting and coughing state
Visual analogue scale (VAS): a 100 mm transverse line with 0mm at one end of the line indicates no pain, 100mm at the other end indicates severe pain and the middle part shows different levels of pain.
Time frame: 1hour, 2hours, 4hours, 8hours and 24hours after surgery
The value of central venous pressure
ultrasound-guided internal jugular vein catheterization connected with transducer
Time frame: 5min, 10min, 15min and 30min after nerve block
QoR-15 scores
The QOR-15 scale was scored from 0 (very poor QoR) to 150 (excellent QoR). A higher score indicates a better patient status.
Time frame: before and 24h after surgery
Quantitative assessment of liver function
The levels of plasma liver function markers AST and ALT before and after liver resection.
Time frame: before and 1days, 3days after surgery
Postoperative Complications
Including nausea, vomiting, pruritus, dizziness, headache, constipation, urinary retention, respiratory depression and so on.
Time frame: 2hours, 4hours, 8hours and 24hours after surgery
Recovery time nodes
drainage tube removal time, offbed activity, or postoperative hospital stay, etc.
Time frame: follow up patients for an average of half a month
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