The aim of the study is to assess the number of patients with elevated blood tryptase for whom this elevation could be linked to a hereditary alpha-tryptase secretion abnormality or hyper-alpha-tryptasemia. This information will enable to better optimize the management and follow-up of patients who have experienced hypersensitivity reactions and have elevated basal blood tryptase levels. The patients will be offered the opportunity to take part in the study. If they consent to participate, they will be tested for hereditary hyper-alpha-tryptasemia. A blood sampling will be performed in the center. A few weeks after, the patient will be informed about the blood sample result during a medical consultation organized in the center.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
100
Patients who came to the pneumoallergology department of the CHU de Nice since January 2014 for an allergological workup and with tryptasemia was ≥ 8ng/ml (at least once in patient history).
CHU de Nice - Hôpital de Pasteur
Nice, Alpes-Maritimes, France
RECRUITINGPrevalence of hereditary hyper alpha-tryptasemia
Analysis machine by PCR
Time frame: at inclusion
Phenotyping our patient cohort
longitudinal follow-up of clinical symptoms according to patient subgroups in relation to mast cell pathologies.
Time frame: at 36 months
Set up a serotheque to support scientific and medical projects in this field
Biobanking
Time frame: At inclusion
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.