Bemalenograstim Alfa for the Prevention in Patients With Colorectal Cancer/Pancreatic Cancer

Inclusion Criteria: 1. The patients voluntarily joined the study, signed informed consent, had good compliance, and cooperated with follow-up; 2. Age 18 and above, male or female; 3. Patients with locally advanced or advanced colorectal or pancreatic cancer confirmed by histology or cytology are scheduled to receive at least 2 courses of FOLFIRI, FOLFOXIRI, or mFOLFIRINOX with or without targeted therapy as part of first-line therapy (excluding those who relapse within 6 months after the end of adjuvant therapy) ; 4. Eastern Cancer Collaboration Group (ECOG) physical status (PS) score: 0-1; 5. Adequate organ and bone marrow function meets the following criteria: 1. Blood routine examination standards should be met (no blood transfusion or blood products within 14 days, no G-CSF and other hematopoietic stimulating factors are used to correct): hemoglobin content (HB) ≥80g/L; Neutrophil count (ANC) ≥1.5×109/L; Platelet count (PLT) ≥100×109/L. 2. Biochemical examination shall meet the following criteria: Serum total bilirubin (TBIL) ≤1.5 times the upper limit of normal value (ULN); ALT and AST ≤ 2.5 ULN; If with liver metastasis, ALT and AST ≤ 5× ULN; Serum creatinine ≤ 1.5× ULN. 3. Left ejection fraction \>50%. 6. Infertile women, i.e. those who have been through menopause for at least one year or who have undergone sterilization (bilateral tubal ligation, double ovaries removal, or hysterectomy); Fertile patients agreed to use appropriate contraceptive methods: condoms, foam, gel, diaphragm, intrauterine device (IUD), birth control pills (given orally or by injection) for 1 month before the start of the trial and 30 days after the end of the study. 7. The investigators determined that the patient could tolerate the treatment of Bemalenograstim Alfa. Exclusion Criteria: 1. Acute congestive heart failure, cardiomyopathy, or myocardial infarction as diagnosed by clinical, electrocardiogram or other means; 2. Rubber allergic people; 3. Patients who had received radiotherapy for bone lesions (patients who had received radiotherapy for lesions other than bone lesions could be enrolled 4 weeks later) ; 4. Have received a bone marrow or stem cell transplant; 5. Pregnant or lactating women; 6. Known to be seropositive for human immunodeficiency virus (HIV) or have AIDS; 7. Active tuberculosis disease; Or a recent history of contact with a person with TB, unless the tuberculin test is negative, Or tuberculosis patients undergoing treatment; Or a chest radiograph to check suspected cases; 8. Patients with alcohol or substance abuse, which affected their adherence to the study;以上 9. Known allergy to granulocyte colony-stimulating factors or excipients of drugs; 10. Received recombinant human granulocyte stimulating factor treatment within 6 weeks before inclusion; 11. Patients with a diagnosis of primary malignancy other than colorectal or pancreatic cancer were accompanied by the following, except: 1) malignancy in complete remission for at least 2 years prior to enrollment and without additional treatment during the study period; 2) non-melanoma skin cancer or malignant lentigo with adequate treatment and no evidence of disease recurrence; 3) Carcinoma in situ with adequate treatment and no evidence of disease recurrence; 12. Use of other investigational drugs within 1 month prior to study enrollment; 13. The investigators believe that the patients have diseases or symptoms that are not suitable for participation in the study and that the study drugs may harm the patient's health or affect the judgment of adverse events;