Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis

Medical University of Warsaw55 enrolled

Overview

The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aortic Stenosis Aortic Valve Disease Aortic Valve Calcification

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * aortic valve replacement or heart transplant as part of standard care decided by the local Heart Team * pre-surgical computed tomography angiography * informed consent

Locations (2)

Medical University of Silesia

Katowice, Poland

RECRUITING

Poznan University of Medical Sciences

Poznan, Poland

RECRUITING

Outcomes

Primary Outcomes

Aortic valve tissue composition measured from pre-procedural computed tomography angiography

Quantitative analysis of aortic valve composition will be based on pre-surgical planning CTA images using semi-automated software (Autoplaque version 2.5, Cedars-Sinai Medical Center, Los Angeles, CA, USA) for calcified, non-calcified and total tissue volumes.

Time frame: up to 30-days before surgery

Aortic valve tissue composition measured from quantitative histology

Different stains will be used to characterize composition of excised aortic valves (hematoxylin and eosin, Movat Pentachrome, Van Gieson's trichrome, Congo Red, anti-CD68 antibody

Time frame: immediately post-surgery

Central Contacts

Kajetan Grodecki, MD, PhD

CONTACT

0048 660675782 kajetan.grodecki@gmail.com

Data from ClinicalTrials.gov

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