CT-100 is a platform that provides interactive, software based therapeutic components that may be used as part of a treatment in future software-based prescription digital therapeutics. One class of CT-100 components are Digital Neuro-activation and Modulation (DiNaMo) components. DiNaMo components target key neural systems (including but not limited to systems related to sensory-, perceptual-, affective-, pain-, attention-, cognitive control, social- and self-processing) to optimally improve a participant's health.
CT-100 is a platform that provides interactive, software based therapeutic components that may be used as part of a treatment in future software-based prescription digital therapeutics. One class of CT-100 components are Digital Neuro-activation and Modulation (DiNaMo) components. DiNaMo components target key neural systems (including but not limited to systems related to sensory-, perceptual-, affective-, pain-, attention-, cognitive control, social- and self-processing) to optimally improve a participant's health. Targeted cognitive training is used to reduce symptoms relevant to multiple sclerosis (MS) and cancer. Biases to direct attention towards or away from certain stimuli can exacerbate a variety of symptoms in many different indications. For example, in chronic pain conditions, patients are more attentive to pain-related stimuli, which can lead to hypersensitization. Similarly, hypersensitivity to threat-related stimuli can exacerbate anxiety. In this treatment, users are trained to re-orient attention away from negative stimuli, such as pain- or threat-related stimuli.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
194
Attention Biases App CT-100-D-004-A Digital Neuro-activation and Modulation (DiNaMo) component uses implicit training to redirect and strengthen attention processes. This intervention can help improve cognitive capabilities as well as redirect attentional biases to make participants less sensitive to distressing stimuli.
Attention Biases App CT-100-D-004-B Digital Neuro-activation and Modulation (DiNaMo) component uses implicit training to redirect and strengthen attention processes. This intervention can help improve cognitive capabilities as well as redirect attentional biases to make participants less sensitive to distressing stimuli.
Click Therapeutics
New York, New York, United States
Change in Patient Reported Outcomes
Change from baseline to Week 4 in quality of life as measured by PROMIS-29+2 (Patient Reported Outcomes Measurement Information System)
Time frame: Baseline to Week 4
Change in Pain Severity and Pain Interference
Change from baseline to Week 4 in pain severity and pain interference as measured by the Brief Pain Inventory (BPI)
Time frame: Baseline to Week 4
Change in Pain Catastrophizing Scale
Change from baseline to Week 4 Pain Catastrophizing Scale (PCS) from 0-30+
Time frame: Baseline to Week 4
Change in indication-specific measures MS
Change from baseline to Week 4 in indication-specific measures: Symbol Digit Modalities Test (SDMT) for MS
Time frame: Baseline to Week 4
Change in indication-specific measures Cancer
Change from baseline to Week 4 in indication-specific measures: Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog) for cancer
Time frame: Baseline to Week 4
Proportion of participants with an improvement
Proportion of participants with an improvement as measured by the Global Rating of Change (GRC) score from -5 to 5 at Week 4
Time frame: Baseline to Week 4
Engagement with Study App
Engagement with the Study App as measured by daily time in the Study App
Time frame: Baseline to Week 4
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.