Screening for risk factors related to lung function impairment in patients who have recovered from AIDS with severe pneumonia, to provide clinical evidence for early identification and intervention of lung function damage in this population.
This is a prospective, single-center, non-randomized, clinical observational cohort study. It involves monitoring lung function at discharge (baseline, 0w), and at the 4th, 8th, 12th, 24th, and 48th weeks in patients recovering from severe pneumonia with AIDS. Basic demographic data, HIV RNA quantification, routine blood tests, blood biochemistry, arterial blood gas results, oxygenation index, immune function (CD3+, CD4+, CD8+ T cell counts), and imaging studies are also collected. Multifactorial logistic regression analysis is used to screen for clinical predictors of lung function decline in patients recovering from severe pneumonia
Study Type
OBSERVATIONAL
Enrollment
100
Guangzhou Eighth People's Hospital, Guangzhou Medical University
Guangzhou, Guangdong, China
RECRUITINGObstructive Ventilatory Dysfunction
FEV1(Forced Expiratory Volume in One Second )to FVC (Forced Vital Capacity ) Ratio
Time frame: 12 weeks
FEV1
FEV1 decrease of ≥100 mL
Time frame: 12 weeks
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