This study aims to assess the risk factors and evaluate the long-term outcomes of patients with coronary chronic total occlusion (CTO) treated with percutaneous coronary intervention or medical treatment.
Coronary artery disease (CAD) is still one of the major contributors to global mortality. CTO is a special lesion type of CAD, defined as complete occlusion of at least one major epicardial coronary artery more than 3 months. Compared to non-CTO patients, those with CTO have worse prognosis. The prognosis of CTO patients is related to many factors including the baseline characteristics, modality of treatment and the degree of coronary collateral formation. Figuring out the factors which can indicate the outcomes of CTO is essential to clinical decision making. In this single center, observational study, we collect patient's clinical characteristics and blood samples to investigate potential factors associated with the development of coronary collateral formation and outcomes in patents with stable coronary artery disease.
Study Type
OBSERVATIONAL
Enrollment
3,000
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, China
RECRUITINGThe degree of collateral estimated visually by Rentrop score during coronary angiography
The degree of coronary collateralization supplying the distal area of the total coronary occlusion was visually graded using the Rentrop scoring system as follows: 0=no visible collaterals; 1=poorly opacified collaterals with faint visualization of the distal vessel; 2=partial filling of the collateral vessels; and 3=complete filling of the collateral vessels. Patients were then classified as poor coronary collaterals (Rentrop scores of 0 and 1) or good coronary collaterals (Rentrop scores of 2 and 3), according to the Rentrop score.
Time frame: Immediate post-angiography
Composite event of all-cause mortality, non-fatal myocardial infarction, heart failure and repeat revascularization
Time frame: up to 5 years
Event of all-cause mortality
Time frame: up to 5 years
Event of death from cardiac causes
Time frame: up to 5 years
Event of heart failure
Time frame: up to 5 years
The change of left ventricular ejection fraction
Time frame: 1 year
Events of repeat revascularization
Time frame: up to 5 years
Event rate of procedural success
Time frame: Immediate post-PCI
Event of procedural outcomes
Time frame: 1 month post-angiography or PCI
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