The goal of this double-center, double-blind, randomized controlled clinical trial is to compare the effect of intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. The main question it aims to answer are whether intravenous lidocaine reduce postoperative pulmonary complications in patients undergoing minimally invasive esophagectomy. Participants will be given intravenous lidocaine infusion in lidocaine group or placebo in control group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
770
Lidocaine bolus of 2mg/kg after induction , and then continuous infusion with 2 mg/kg/h until the participate transfer out of postoperative anesthesia care unit.
Same volume of normal saline in bolus and continuous infusion as lidocaine group.
Incidence of PPCs
Pulmonary complications is defined as one or more of the following complications: respiratory infection; respiratory failure; pneumothorax;atelectasis; pleural effusion; bronchospasm; aspiration pneumonitis; anastomotic fistula
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
respiratory infection
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
respiratory failure
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
pneumothorax;atelectasis
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
pleural effusion
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
bronchospasm
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
aspiration pneumonitis
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
anastomotic fistula
Time frame: 1, 2, 3, 4, 5, 6, 7 days after surgery
moderate to severe pain within 24 and 48 hours at rest and when coughing
Time frame: 24 and 48 hours after surgery
moderate to severe pain within 24 and 48 hours at coughing
Time frame: 24 and 48 hours after surgery
additional rescue analgesics use
Time frame: 24 and 48 hours after surgery
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.