Perioperative anesthesia can affect postoperative cognitive function. In our previous study, intraoperative dexmedetomidine (Dex) infusion reduced the incidence of delirium within the first 5 days after brain tumor. However, the mechanism is still unclear. With the development of neuroimaging, multimodal neuroimaging technology provide a new method to explore the underlying mechanism. Therefore, the purpose of this study is to analyze the alterations of brain network under sedation and anesthesia by different anesthetics in patients with supratentorial glioma and their association with cognition.
Study Type
OBSERVATIONAL
Enrollment
120
Participants will be sedated and maintained by dexmedetomidine during the surgery.
Participants will be sedated and maintained by propofol during the surgery.
Participants will be sedated and maintained by remimazolam during the surgery.
Beijing Tian Tan Hospital, Capital Medical University
Beijing, Beijing Municipality, China
RECRUITINGThe alterations of brain network connectivity.
fMRI and DTI will be used to detect brain network connectivity.
Time frame: Before sedation, 30 minutes after sedation，and 30 minutes after surgery.
Postoperative delirium.
The incidence and severity of postoperative delirium and its association with changes of brain network connectivity.
Time frame: Day 1-5 after surgery.
Electroencephalogram changes
Electroencephalogram will be used to record the brain activity.
Time frame: From patients admission to operation room until 10 minutes after surgery
rScO2 changes.
Regional cerebral oxygen saturation (rScO2) will be monitored with near-infrared spectroscopy (NIRS).
Time frame: From patients admission to operation room until 10 minutes after surgery
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