The purpose of this study is to assess how well a new scoring system called the 5-SENSE score can predict where seizures start in the brain using Stereoelectroencephalography (SEEG). The 5-SENSE Score is a 5-point score based on routine presurgical work-up, designed to assist in predicting whether SEEG can identify a focal seizure onset zone, thereby sparing patients the risk of undergoing this invasive diagnostic procedure.
Study Type
OBSERVATIONAL
Enrollment
400
Participants will under Stereoelectroencephalography (SEEG) as part of standard of care. This is not assigned by the protocol.
University of Florida College of Medicine
Gainesville, Florida, United States
Northwestern University
Specificity of the 5-SENSE score for the identification of a focal SOZ on SEEG
Prospective validation of the predictive value of the 5-SENSE score to identify a focal seizure onset zone (SOZ) in an independent patient sample. Measured for participants undergoing SEEG.
Time frame: At time of SEEG, up to approximately 1 month
Sensitivity of the 5-SENSE score for the identification of a focal SOZ on SEEG
Prospective validation of the predictive value of the 5-SENSE score to identify a focal seizure onset zone (SOZ) in an independent patient sample. Measured for participants undergoing SEEG.
Time frame: At time of SEEG, up to approximately 1 month
Positive predictive value of the 5-SENSE score for the identification of a focal SOZ on SEEG
Measured for participants undergoing SEEG
Time frame: At time of SEEG, up to approximately 1 month
Negative predictive value of the 5-SENSE score for the identification of a focal SOZ on SEEG
Measured for participants undergoing SEEG
Time frame: At time of SEEG, up to approximately 1 month
Specificity of the 5-SENSE score augmented by information from auxiliary diagnostic methods for the identification of a focal SOZ on SEEG
For participants undergoing SEEG, information from auxiliary diagnostic methods, performed routinely during presurgical evaluation, namely FDG-PET, electrical source imaging (ESI) and/or magnetic source imaging (MSI) and ictal HMPAO-SPECT will be analyzed. The investigators will assess whether addition of those variables to the 5-SENSE Score could enhance score performance with higher specificity for identifying a focal SOZ
Time frame: At time of SEEG, up to approximately 1 month
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Chicago, Illinois, United States
Duke University Health System
Durham, North Carolina, United States
Presbyterian-Shadyside Hospital
Pittsburgh, Pennsylvania, United States
Monash University
Melbourne, Victoria, Australia
Mater Health
Brisbane, Australia
Alfred Health
Melbourne, Australia
Christian Doppler University Hospital Paracelsus Medical University Salzburg and Centre for Cognitive Neuroscience Salzburg
Salzburg, Austria
Dalhousie Universiry and Hospital
Dalhousie, Nova Scotia, Canada
Wester University
London, Ontario, Canada
...and 9 more locations
Sensitivity of the 5-SENSE score augmented by information from auxiliary diagnostic methods for the identification of a focal SOZ on SEEG
For participants undergoing SEEG, information from auxiliary diagnostic methods, performed routinely during presurgical evaluation, namely FDG-PET, electrical source imaging (ESI) and/or magnetic source imaging (MSI) and ictal HMPAO-SPECT will be analyzed. The investigators will assess whether addition of those variables to the 5-SENSE Score could enhance score performance with higher sensitivity for identifying a focal SOZ
Time frame: At time of SEEG, up to approximately 1 month
Concordance of the 5-SENSE Score with the decision whether to proceed with SEEG or not
Before SEEG, the decision whether to proceed with SEEG or not is made blinded from the 5- SENSE Score in a Multidisciplinary Team Discussion (MTD). Following the decision, the 5-SENSE Score will be calculated for each participant by the principal investigator. Concordance of the 5-SENSE Score with the decision made in the MTD will be assessed.
Time frame: At enrollment