Studies to Gain Insight How the Drugs PCSK9-inhibitors and Statins Affect Cholesterol and Bile Acid Metabolism

Inclusion Criteria: * Male * \>18 years of age Exclusion Criteria: * Cardiovascular disease * Cerebrovascular disease (e.g. stroke, prior aneurysm) * Pulmonary disease (e.g. pulmonary hypertension, COPD) * Metabolic disease (incl. but not limited to Cushing disease, Diabetes) * Renal disease (by Chronic kidney disease criteria) * Active inflammatory bowel syndrome * Cancer * Pregnancy * Smoker * Any chronic medication use * Steroid treatment for the last six months or hormone replacement therapy * Coagulopathy * Musculoskeletal or neurologic disease * Know allergy against any of the studied substances * Inclusion in any other concurrent medical research study