Evaluation of Dentifrice Formulations to Remineralize Enamel and Dentine Subsurface Lesions in a Double-Blind In-Situ Clinical Trial

Inclusion Criteria: * Be 18-75 years of age; * Provide written informed consent prior to participation and be given a signed copy of the informed consent form; * Be in good general health based on medical/dental history and oral exam; * Have no history of adverse or allergic reactions to tin or tin-containing products; * Agree not to participate in any other oral study for the study duration; * Have a reasonable functional dentition as determined by the oral examiner and sufficient teeth to support the fabricated dental appliance; * Be willing to participate in the study, able to follow the study directions, successfully tolerate/perform all study procedures, and willing to return for all specified visits at their appointed time; * Be willing to refrain from using non-study dentifrice, mouth rinse, chewing gum, and other non-study oral care products during the study; * Be willing to postpone all elective dental procedures until the study has been completed; * Be willing to refrain from using calcium chews while using the test products; * Be willing and able to refrain from wearing a nightguard (occlusal splint) for the entire course of the study (for nightguard wearers only). * Ability to understand, and ability to read and sign, the informed consent form; * Have at least 22 natural teeth; * Have a gum-stimulated whole salivary flow rate ≥1.0 ml/minute and unstimulated whole salivary flow rate ≥ 0.2 ml/minute. * Willingness to comply with all study procedures and be available for the duration of the study. Exclusion Criteria: * Advanced periodontal disease, as characterized by purulent exudate, generalized mobility, and/or severe recession; * Active treatment for periodontitis; * A medical condition which requires premedication prior to dental visits/procedures; * Untreated dental problems (e.g. cavities); * Self-reported pregnancy or plans to become pregnant during the study; * Existing dental work which prevents wearing of the appliance including orthodontic appliances or removable dentures; * Chronic disease such as diabetes or use of medications that cause gum swelling; * Any diseases or conditions (including sensitivity to dentifrice ingredients or a history of allergic or adverse reactions to tin or tin-containing products) that might interfere with examination procedures or the participant safely completing the study; * Treatment with antibiotics or anti-inflammatory medicines in the month prior to starting the study; * Use of drugs that may interact with the toothpaste slurries or which may affect salivary flow rate; * History of health conditions requiring antibiotic coverage prior to dental treatment; * Serious infectious disease; * Any other medical or dental conditions deemed to put the health and wellbeing of the participant or research team at risk if the potential participant participated in the study.