We compared the time consumed for goal-directed management of hypofibrinogemia using two strategies during liver transplant (LT) surgery: a conventional cryoprecipitate-based strategy versus a lyophilized fibrinogen concentrate-based strategy
The primary outcome is an inter-group comparison of treatment time (T-time, the duration from ordering cryoprecipitate or FC to completing its administration). The secondary measures include comparisons of perioperative bleeding, blood transfusion, coagulation profiles, reoperation, thromboembolic complications, mortality, oxygenation profiles, fibrinolysis phenotypes, and costs for bleeding management and length of hospital stay.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
92
transfusion of fresh frozen plasma
prothrombin complex concentrate administration
Samsung Medical Center
Seoul, South Korea
intergroup difference in the treatment time (T-time)
The treatment time (T-time): the duration from ordering cryoprecipitate or FC to completing its administration
Time frame: 1 min
Red Blood Cell amount
Red Blood Cell transfusion amount during surgery
Time frame: 1 hour
FFP amount
FFP transfusion amount during surgery
Time frame: 1 hour
Platelet amount
Platelet transfusion amount during surgery
Time frame: 1 hour
r-time
CK r-time after PCC or FFP
Time frame: 1 min
CRT-MA
CRT-MA after PCC or FFP
Time frame: 1 min
CFF-MA
CFF-MA after PCC or FFP
Time frame: 1 min
Bleeding
Postoperative bleeding amount
Time frame: 6 hour
oxygenation profile
PaO2/FiO2 ratio
Time frame: 1 hour
preparation time of cryoprecipitate or FC
time from the start of preparation (ABO-cross matching and thawing of cryoprecipitate or unpacking FC from its storage) to the delivery to patients in the operation theater
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Time frame: 1 min