The primary aim of this study is to assess the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+Dipeptidyl peptidase 4 (DPP-4) inhibitors in poorly controlled type 2 diabetes mellitus (T2DM) patients. The study seeks to evaluate its effect on achieving glycemic goals in this patient population.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
150
the impact of incorporating Empagliflozin, an oral sodium-glucose co-transporter 2 (SGLT2) inhibitor, into the existing therapeutic regimen of Insulin+Metformin+DPP4 inhibitor (DPP4I) in poorly controlled type 2 diabetes mellitus (T2DM
Group B: usual care group but without Empagliflozin with adjustment of therapy as the standard of care
SINA Shireen Jinnah colony
Karachi, Pakistan
Number of participants achieved HbA1c level i.e. <7%
The foremost objective is to determine whether the addition of Empagliflozin to the current treatment regimen leads to a significant improvement in glycemic control i.e. glycated haemoglobin less than 7% among poorly controlled T2DM patients in three months of treatment
Time frame: 12 weeks
Weight in Kg
Number of participants reduces weight in Kg during the therapy or mean reduction in weight overtime
Time frame: 12 weeks
BMI in kg/m2
Number of participants reduces BMI kg/m2 or mean reduction in BMI overtime
Time frame: 12 weeks
systolic blood pressure and diastolic blood pressure
systolic blood pressure and diastolic blood pressure measure in mmHg during the therapy
Time frame: 12 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.