Effect of Smoking Cessation on Salivary IL-1β and PGE-2 Levels Following Non-Surgical Periodontal Therapy

Inclusion Criteria: * Patients with advanced chronic periodontitis upon clinical examination with clinical attachment loss (CAL) more than 5 mm. * Patients willing to quit smoking to be included in two groups, while patients unwilling to quit smoking to be included in the third group, and the non-smokers as the fourth group. Exclusion Criteria: * Any systemic illness known to affect the outcome. * Systemic antimicrobial or anti-inflammatory drug therapy within the last 3 months prior to the study. * Patients unable to perform routine oral hygiene procedures. * Patients using other forms of tobacco.