The purpose of this study is to evaluate how an oral herbal supplementation influences facial skin elasticity and facial hydration as well as markers of photoaging (erythema and pigmentation).
Skin is the largest organ of the body and skin aging represents a primary indicator of the aging process in the body. Photoaging is among the most crucial factors that cause skin aging damage. Photoaged skin is primarily induced by prolonged exposure to ultraviolet radiation leading to the appearance of increased skin pigmentation, reduced elasticity, and pronounced wrinkles. There has been an increasing recognition of the influence of nutrition on skin health with dietary elements emerging as a viable alternative approach to preventing photoaging. The aim of this study is to understand how oral supplementation impacts photoaged skin, facial hydration, and facial elasticity.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
36
Take one capsule daily
Take one capsule daily
Change in Skin Elasticity
Skin elasticity measured with a handheld non-invasive device (Cutometer, Delfin Technologies Ltd.)
Time frame: 8 weeks
Change in Skin Hydration
The skin capacitance will be measured with a handheld non-invasive device (Skin MoistureMeterSC, Delfin Technologies Ltd.). The measurement is in arbitrary units per manufacturer.
Time frame: 8 weeks
Change in skin pigmentation intensity
Facial photographs will be obtained and analyzed utilizing the BTBP 3D Clarity Pro Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA, USA). The measurement will analyze pigment intensity and will be reported as a relative change from baseline.
Time frame: 8 weeks
Change in appearance of facial wrinkles
Facial photographs will be obtained and analyzed utilizing the BTBP 3D Clarity Pro Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA, USA). The measurement will analyze wrinkle severity that is a measure of both the wrinkle depth and width and will be reported as a relative change from baseline.
Time frame: 8 weeks
Change in the skin erythema
Facial photographs will be obtained and analyzed utilizing the BTBP 3D Clarity Pro Facial Modeling and Analysis System (Brigh-Tex BioPhotonics, San Jose, CA, USA). The measurement will analyze erythema intensity and will be reported as a relative change from baseline.
Time frame: 8 weeks
Change in skin transepidermal water loss
Skin transepidermal water loss measured with a handheld non-invasive device (Vapometer, Delfin Technologies Ltd.)
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Time frame: 8 weeks
Self-perception of skin (changes in facial fine lines and wrinkles, firmness, etc)
Assessed with the use of a subjective questionnaire to be completed by participants. Self-perception will be measured by rating symptoms of skin improvement, clarity, smoothness, etc.)
Time frame: 8 weeks
Product Tolerability
Assessed with the use of a tolerability questionnaire to be completed by participants. Tolerability will be measured by rating symptoms such as burning, stinging, and scaling.
Time frame: 8 weeks