The aim of this study is to compare the efficacy double trigger \[ co-administration of GnRH agonist with HCG 40 and 34 h prior to ovum pick-up, respectively\] with HCG trigger in inducing oocyte maturation.
Several studies revealed that the double trigger regimen was effective in the treatment of patients with a history of immature oocytes retrieved or with suboptimal oocytes yield. The investigators designed this randomized controlled trial to compare the efficacy double trigger with HCG trigger in inducing oocyte maturation.in normoreponders undergoing IVF-ET
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
150
GnRH agonist ( Triptorelin ) ( 0.2 mg / S.C ) and hCG ( 10000 IU) are administered 40 and 34 h before ovum pick-up
hCG ( 10000 IU) is administered 36 h before ovum pick-up
Bedaya Hospital
Giza, Egypt
Metaphase-II oocytes rate
Number of MII oocyte/ number of cumulus oocyte complex
Time frame: Ten to fifteen days after starting ovarian stimulation
Clinical pregnancy rate
Presence of intrauterine gestational sac detected by transvaginal ultrasound
Time frame: 5 weeks after embryo transfer
Ongoing Pregnancy Rate
Pregnancies continued beyond 20 weeks gestation
Time frame: 18 weeks after embryo transfer
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