A research-initiated prospective cohort study with the aim to assess the effectivity, safety and long-term outcomes after surgical and endovascular treatment of unruptured intracranial aneurysms. All consecutive patients with a non-ruptured intracranial aneurysms treated at Helsinki University Hospital will be included. Safety is measured by postoperative magnetic resonance imaging (MRI) taken 1-3 days after the treatment, treatment-related complications and functional outcome at three months. Effectiveness is measured by angiographic results and assessment of long-term bleeding from the treated aneurysm. Other outcomes include risk of developing epilepsy, getting a new stroke, and dementia on long-term follow-up.
Study Type
OBSERVATIONAL
Enrollment
173
Surgical treatment for the unruptured intracranial aneurysm
Endovascular treatment for the unruptured intracranial aneurysm
Helsinki University Hospital
Helsinki, Uusimaa, Finland
New ischemic lesion on postoperative MRI
Diffusion-Weighted Imaging lesion
Time frame: 1-3 days
Neurological symptom
New procedure-related neurological symptom
Time frame: 3 months
Return to work
Days from intervention to return to work
Time frame: 3 months
Functional outcome
modified Rankin Scale (mRS going from 0 \[no sympyoms\] to 6 death\])
Time frame: 3 months
Aneurysm occlusion on angiography
Rate of occluded vs. incompletely occluded aneurysms. Assessed through digital subtraction angiography, CTA or MRA. Routine controls for endovascularly treated patients 6mo, 2y, and if needed 5y. Routinely assessed by a postoperative CTA for surgically treated patients.
Time frame: 6mo - 5yrs
Patients with late rebleeding from the target aneurysm
Number of patients with rebleeding (subarachnoid hemorrhage \[SAH\]) from the treated aneurysm
Time frame: up to 10 yrs
Epilepsy
Number of patients with a new diagnosis of epilepsy after aneurysm treatment
Time frame: up to 10 yrs
Dementia
Number of patients with a new diagnosis of dementia after aneurysm treatment
Time frame: up to 10 yrs
Other stroke than aneurysm bleed
Number of patients with a new stroke (other than SAH from the treated aneurysm) after aneurysm treatment
Time frame: up to 10 yrs
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