A Comparison Between Dexmedetomidine and Propofol-fentanyl Infusions for Sedation for Colonoscopy Procedures

Zulekha Hospitals60 enrolled

Overview

Background: Different intravenous sedative drugs have been utilized for colonoscopy, with many anesthetists for painless sedation or monitored anesthesia care. The aim of this study was the quality of colonoscopy and the incidence of adverse events such as respiratory depression, hemodynamic instability, and failure to provide adequate sedation.

Background: Different intravenous sedative drugs have been utilized for colonoscopy, with many anesthetists for conscious sedation or monitored anesthesia care. Aim of this study was the quality of colonoscopy and the incidence of adverse events such as respiratory depression, hemodynamic instability, and failure to provide adequate sedation. Patients and methods: Sixty patients of both sexes and 21-60 years old with ASA physical status I-II, were randomly assigned to receive either dexmedetomidine (D group) or propofol-fentanyl (PF group) infusions in equal numbers. Minimal infusion rates of dexmedetomidine (0.1-0.4 μg/kg/h) in the D group and fentanyl (0.01-0.05 μg/kg/min) in the PF group were continued during colonoscopy, which lasted approximately 30 minutes.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

SINGLE

Enrollment

Conditions

Anxiety and Fear

Interventions

Patients who received DexmedetomodineDRUG

1 microgram/kg over a period of 10 minutes, and then a maintenance infusion was titrated in a range from 0.2-1 μg/kg/h).

patients who received propofol-fentanylDRUG

Continued infusions of both fentanyl and propofol were 0.01-0.05 μg kg/ min 25-150 mg/h respectively.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

* Inclusion Criteria: 1. both sexes 2. 21-60 years old, with 3. ASA physical status - * Exclusion Criteria: * severe cardiovascular or respiratory disease * (ASA grade ≥III) * pregnancy * allergies to the drugs being used * known alcohol or substance abuse * expected communication difficulties with the patient.

Locations (1)

Al-Azhar faculty of medicine

Cairo, Egypt

Outcomes

Primary Outcomes

The quality of painless sedation during colonoscopy.

The patient's ability to cooperate and perform the procedure was evaluated using a 10-point numerical rating scale (NRS).

Time frame: From start of procedure to 120 minutes after end of colonoscopy

Secondary Outcomes

incidence of adverse events, Prevalence of adverse effects

incidence of adverse events, hemodynamic instability, failure to provide adequate sedation.

Time frame: from start of procedure to 120 minutes after end of colonoscopy

Data from ClinicalTrials.gov

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