Muscle Parameters and Pathological Response in Breast Cancer Patients

Acıbadem Atunizade Hospital69 enrolled

Overview

The investigators aimed to accurately measure muscle mass and predict pCR to NAC and its effect on clinical outcomes.

In patients with operable breast cancer (BC) receiving neoadjuvant chemotherapy (NAC), the pathological response rate was found to be related to body composition. The success of complete pathologic response (pCR) is a known prognostic factor in BC patients treated with NAC. The investigators aimed to accurately measure muscle mass and predict pCR to NAC and its effect on clinical outcomes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Neoadjuvant Chemotherapy

Interventions

Neoadjuvant therapyOTHER

To measure muscle mass and predict pCR to NAC and its effect on clinical outcomes.

Eligibility

Sex: FEMALEMin age: 29 YearsMax age: 72 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Early and locally advanced operated breast cancer patients receiving neoadjuvant chemotherapy. Exclusion Criteria: * Patients who did not receive neoadjuvant chemotherapy, had metastatic breast cancer and whose radiological images were not available.

Locations (1)

AcıbademAH

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Sarcopenic index

skeletal muscle area (cm2)/height (m2) et L3 level

Time frame: Through study completion, an average of 1 year.

Secondary Outcomes

Body mass index

weight (kg)/height (m2)

Time frame: Through study completion, an average of 1 year.

Data from ClinicalTrials.gov

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