A Study to Evaluate XTR006 in Chinese Volunteers

Inclusion Criteria: 1. Male and female subjects between 50-70 years (included 50 \& 70 years old) will be included; 2. Healthy or without serious diseases evaluated by the investigator based on the followings: medical history, vital signs, physical examination, electrocardiogram and clinical laboratory test results; 3. Electroencephalogram（EEG）examination result is "normal"; 4. Aβ PET imaging is negative; 5. Mini-Mental State Examination (MMSE) score ≥ 28; 6. Normal routine blood and urine examination, liver function test, renal function test, biochemical test of serum troponin T and myocardial enzymes, or the abnormality of any test with no clinical significance; 7. Female subjects must take effective contraceptive measures during the study period and within 6 months after the last visit (effective contraceptive measures include sterilization, intrauterine hormone devices, condoms, contraceptives/agents, abstinence or partner removal of the vas deferens, etc.). Male subjects should agree to take contraception during the study period and within 6 months after the last visit; 8. Sign the informed consent form. Exclusion Criteria: 1. Any previously diagnosed brain disease, such as cerebrovascular disease, inflammatory or infectious disease or any neurodegenerative disease, including any history of Parkinson's disease by physical or imaging manifestations, or history of traumatic brain injury, history of brain surgery or cranial internal hematoma by permanent brain injury; 2. Any history of severe diseases or undergoing unstable disease (such as unstable angina pectoris, dilated or hypertrophic cardiomyopathy, valvular heart disease, congenital heart disease, myocardial infarction, heart failure, chronic renal failure, chronic liver disease, severe lung disease, blood disease, diabetes, chronic infection, epilepsy, or mental illness); 3. The result of cranial magnetic resonance imaging (MRI) met the following imaging criteria: ① More than two infarct regions (diameter greater than 2 cm) outside the brain stem. ② Critical lacunar infarction, such as thalamus, hippocampus, entorhinal cortex and angular gyrus. ③ Fazekas score of high white matter damage ≥ 3 or minor axis of enlarged perivascular space (EPVS) \> 3 mm determined by MRI examination; 4. Family history of dementia; 5. Medication in the past week or at the present that may interfere the result of clinical trial evaluated by the investigator; 6. Human immunodeficiency virus (HIV) hepatitis C or past test result of treponema pallidum antibody is positive, or hepatitis B surface antigen is positive; 7. History of coagulation disease or present coagulation disorder; 8. History of liver or gastrointestinal diseases or other conditions that can interfere the drug absorption, distribution, excretion or metabolism evaluated by the investigator; 9. Tumor history; 10. High risk of drug allergy (such as allergic asthma patients) or history of severe reactions to allergens; 11. Hyperreactive to alcohol; 12. History of alcohol or drug abuse; 13. Significant occupational exposure to ionizing radiation (e.g. more than 50 mSv/year), exposure to radioactive substances, ionizing radiation for therapeutic or research purposes in the past 10 years; 14. Completion of any medicine or treatments that may cause serious side effects or interfere the clinical trial's data evaluated by the investigator; 15. Participating other drug's clinical trial within 30 days before the enrollment; 16. Pregnant or lactating female; 17. Hospitalization due to illness during the screening period; 18. Other inappropriateness to the trial evaluated by the investigator.