Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.

University of Pecs43 enrolled

Overview

Introduction: Septic shock leads to high morbidity and mortality in critically ill patients. Several lower-case scientific studies have supported the synergistic positive effect of vitamin C, thiamine, and hydrocortisone on sepsis-induced organ dysfunction. Aim: Our aim was to investigate the effect of vitamin complex on organ failure, laboratory parameters, respiratory and antibiotic treatment, intensive care time, and mortality in septic shock patients. Material and methods: In our retrospective and prospective analysis, we collected parameters from 43 (23 vitamin-treated, 20 control) septic shock patients. Patients treated with vitamin, they received vitamin C (4x1500 mg), thiamine (2x200 mg) for three days (2). In other respects, and for hydrocortisone (200 mg / 24h), both groups of patients received treatment according to the European Sepsis Recommendation. SPSS (V-21) data were used for data collection, Kolmogorov-Smirnov, Wilcoxon, Mann-Whitney U tests were used for statistical analysis. Ethical license: 7849-PTE 2019.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Septic Shock

Interventions

Patients in the intervention group (G1) (n=23) received the combined vitamin therapy: IV vitamin C (1.5 g every 6 hours administered as an infusion over 30 to 60 minutes and mixed in a 100- mL solution of normal saline), hydrocortisone (100 mg in bolus-100 mg in perfusor up to 60 min (200mg 24h),), and thiamine (200 mg every 12 hours administered as an infusion over 30 to 60 minutes and mixed in a 100-mL solution of normal saline) for 3 days.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * septic shock * intensive care unit administration Exclusion Criteria: * under age 18 * above age 80 * moribund patients * pregnant patients * active kidney stone * inability to obtain consent * viral or mixed sepsis * missed dose of vitamin C/ thiamin or hydrocortisone * Physician refused * Vitamin C / Thiamine/ Hydrocortisone for other indications

Outcomes

Primary Outcomes

ventilation

duration of mechanical ventilation (days)

Time frame: intensive care unit discharge (up to 90 days)

vasopressors

length of circulatory support (days)

Time frame: intensive care unit discharge (up to 90 days)

Length of stay

length of Intensive care unit staying (days)

Time frame: intensive care unit discharge (up to 90 days)

main mortality

all-cause mortality (dead/survived) in the intensive care unit

Time frame: intensive care unit discharge (up to 90 days)