Comparison of corneal topography based on oct OCT principle (CASIA2) with Pentacam and Scheimpflug-based biomechanical devices (Corvis ST) in screening and diagnosing keratoconus; and evaluation of the consistency with Pentacam in measuring corneal parameters (such as curvature and thickness).
Study Type
OBSERVATIONAL
Enrollment
200
morphological and biomechanical parameters of corneal were obtain by CASIA2, Pentacam and Corvis ST
Tiajin Eye Hospital
Tianjin, Tianjin Municipality, China
RECRUITINGscreening and diagnosis ability
Evaluate the sensitivity and specificity of parameters measured by CASIA2, Pentacam in diagnosing keratoconus using Receiver operating characteristic curves (ROC), and compare the Ectasia Screening Similarity(ESS)and D-value diagnostic efficacy using Area under the ROC curve (AUROC). Use the Delong test to compare the accuracy of various parameters in diagnosing early keratoconus.
Time frame: one year
Measurement consistency
The independent sample T-test is used to compare inter- group differences in baseline data. Use independent sample T-test and One-way ANOVA to evaluate the consistency of the measurement results (anterior and posterior corneal curvature, corneal refractive index, CCT) obtained by CASIA2 and Pentacam.Finally, the ultimate outcome(such ad:K1 K2 KMax CCT) indicates that the P-value between the two devices is less than 0.05 and ICC-value is more than 0.75.
Time frame: one year
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