NCT06152497 - The Role of Histamine in Muscle Protein Synthesis Following Resistance Training | Crick | Crick

The Role of Histamine in Muscle Protein Synthesis Following Resistance Training

N/ARecruitingNCT06152497

University Ghent50 enrolled

Overview

Blocking histamine H1/H2 receptors blunts chronic endurance training adaptations. The current study addresses the following research question: "What is the influence of histamine H1 signaling on training adaptations following ten weeks of resistance training in human skeletal muscle." Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Enrollment

50

Conditions

Interventions

Oral placebo

H1 blockade: Telfast: 180mg FexofenadineDRUG

H1 blockade: oral blockade with 180mg Fexofenadine

Resistance trainingBEHAVIORAL

Resistance training: lower body exercise

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * 18-45 years * Not to medium physically active Exclusion Criteria: * Smoking * Chronic disease * High blood pressure * Supplement or medication intake * Seasonal allergies * Vegetarian / vegan * Resistance trained

Locations (1)

Department of movement and sports sciences, Ghent University, Belgium

Ghent, Oost-Vlaanderen, Belgium

RECRUITING

Outcomes

Primary Outcomes

Muscle volume

Change in muscle volume

Time frame: Before and after the 10 weeks of resistance training

Maximal dynamic strength of leg press, bench press, bicep curl and leg curl

Change in maximal dynamic strength of leg press, bench press, bicep curl and leg curl

Time frame: Before and after the 10 weeks of resistance training

Muscle fiber hypertrophy in muscle biopsies

Change in muscle fiber hypertrophy in muscle biopsies

Time frame: Before and after the 10 weeks of resistance training

Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)

Change in Matsuda index, to estimate whole body glucose metabolism, will be calculated using an oral glucose tolerance test (OGTT: concentration of glucose and insulin in the blood will be measured before and after drinking 75g glucose)

Time frame: Before and after the 10 weeks of resistance training

Vascular function measured with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)

Change in vascular function with a single passive leg movement (sPLM: change in femoral blood flow measured with Doppler ultrasound before and after one passive flexion/extension of the leg)

Time frame: Before and after the 10 weeks of resistance training

Secondary Outcomes

Blood pressure (systolic and diastolic)

Chance in Blood pressure (systolic and diastolic)

Central Contacts

Wim Derave, Professor

CONTACT

92646326 wim.derave@ugent.be

Data from ClinicalTrials.gov

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