Genetic Test Based Risk Prediction of Early Calcific Aortic Valve Disease in Patients With Bicuspid Aortic Valve

Inclusion Criteria: 1. Patients with confirmed bicuspid aortic valves based on cardiac imaging (echocardiography, CT, MRI) or surgical findings. 2. Early aortic valve calcification group: Patients aged 20-80 with moderate or greater aortic valve stenosis/regurgitation. 3. Normal functioning aortic valve group: Patients aged 20-80 with mild or less aortic valve stenosis/regurgitation. 4. Patients who understand the purpose of the study and voluntarily consent to participate. Exclusion Criteria: 1. Patients with malignant neoplastic diseases or other conditions, such as cerebrovascular accidents, which predict survival of less than 6 months. 2. Patients with unclear presence of bicuspid aortic valves. 3. Patients with stage 3 or higher chronic kidney disease. 4. Patients with other inherited cardiac conditions. 5. Patients with cognitive impairment or hemodynamically unstable patients who have difficulty understanding the study content.