Evaluation of the Elasticity of the Mitral Valve

Centre Hospitalier Universitaire de Saint Etienne30 enrolled

Overview

There is no information in the literature on the mechanobiological characteristics of mitral valve chords in living humans. All examinations were carried out on tissues taken from animals, either from cadavers or from frozen human tissues. The objective is to determine mechanobiological and histological characteristics of the mitral valve chords in living humans, as well as to compare differences in elasticity in different groups (Group A: patients with mitral valve prolapse versus Group B: patients with restrictive ischemic mitral valve).

The prospective study will be conducted on 20 patients, who will be selected consecutively without randomization. The inclusion and exclusion criteria are determined. The harvested tissue will not be frozen and will kept in natural conditions as close as possible.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mitral Valve Disease

Interventions

Data collection on patient history and intraoperative results.OTHER

Data collection on patient history and intraoperative results.

Eligibility

Sex: ALLMin age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: All patients programmed for mitral valve replacement who have more than 45 years old Exclusion Criteria: * Patients with mitral calcification * Mitral valve rheumatic disease * Mitral valve infections * Redo surgery on the mitral valve

Outcomes

Primary Outcomes

Maximum value of Young's modulus

Comparison of elasticity difference between the two groups

Time frame: Hour 1

Secondary Outcomes

First histological evaluation

Determine the histological characteristics of living humans