Reducing consumption of foods of animal origin in favor of more plant-based diets is a major environmental, public health and economic challenge. Data on the health effects of highly vegetalized diets are available only in adults. Few studies report the effect of the level of vegetalization of the maternal diet during pregnancy on the mother's health, and the development and health of the child. The VEGALIM project aims to describe the level of vegetalization of pregnant women's diets and the nutritional quality of their diets early in pregnancy (first trimester) and late pregnancy, and to explore the potential effects on their plasma lipid profile that may impact on their health during pregnancy and the health of the newborn.
Study Type
OBSERVATIONAL
Enrollment
670
We will obtain a global index of vegetalization of the diet (the Plant based Diet Index: PDI) from data obtained using semi-quantitative questionnaires on food frequency (Food Frequency Questionnaire (FFQ)) validated on the national ELFE cohort (French Longitudinal Study from Childhood (https://www.elfe-france.fr)) and completed by women in the 1st trimester of pregnancy (T1) and at delivery.
One tube collection of 4 mL maternal blood in the first trimester and at delivery.
CHU de Nantes
Nantes, Loire-Atlantique, France
RECRUITINGCharacterizing the levels of plant-based food consumption at the beginning of pregnancy (at the end of the first trimester of pregnancy) based on the completion of the Food Frequency Questionnaire (FFQ, scale from 0 to 6 ; 0 being the worst outcome)
Time frame: 25 minutes
Study the evolution of the vegetation score between the 1st and 3rd trimester of pregnancy
Time frame: 6 months
Study changes in diet quality between the 1st and 3rd trimesters of pregnancy
Time frame: 6 months
Studying the association between vegetarian diets in the first trimester of pregnancy and pregnancy outcomes (such as prematurity, birth weight, maternal pathologies not present at the time of inclusion (gestational diabetes, pre-eclampsia, etc.).
Time frame: 6 months
Study the association between diet quality in the first trimester of pregnancy and pregnancy outcomes (such as prematurity, birth weight, maternal pathologies not present at the time of inclusion (gestational diabetes, pre-eclampsia, etc.).
Time frame: 6 months
Study the association between the vegetalization of the diet and the lipid profile of women in the 1st trimester and at childbirth.
Time frame: 6 months
Study the association between diet quality and lipid profiles of women in the 1st trimester and at childbirth.
Time frame: 6 months
Study the association between the vegetalization of the diet and the total fatty acid status of women in the 1st trimester and at childbirth.
Time frame: 6 months
Study the association between diet quality and total fatty acid status in women at 1st trimester and at childbirth.
Time frame: 6 months
Identify other biological markers, such as vitamins, that may be impacted by a change in diet, and study the influence of diet quality on these potential plasma markers of patient and of Umbilical cord blood plasma.
Time frame: 6 months
Study the association between diet quality and the lipid profile of umbilical cord blood at delivery (T3).
Time frame: 6 months
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