The Combination of Sperm Selection by IMSI and Hyaluronic Acid Binding Assay May Improve ICSI Outcome.

Meir Medical Center189 enrolled

Overview

In this prospective randomized sibling-oocytes blinded study, investigators examine the combination of two sperm selection methods that logically seem to complete each other, and potentially may improve ICSI outcomes. The methods include the selection of the optimal spermatozoa based on its morphology by IMSI, together with its physiological function of binding to HA by Spermslow (SS). The current study compared a group of ET after sperm selection by IMSI with SS to a group of ET after sperm selection by IMSI-only without SS, and to a mixed ET group where two embryos were transferred, one after IMSI-only and the other one after IMSI with SS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

189

Conditions

Fertility Issues

Interventions

Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI)

Sperm selection by IMSI and spermslowPROCEDURE

Intracytoplasmic morphologically selected sperm injection (IMSI) is a sperm selection method used in intracytoplasmic sperm injection (ICSI) + spermslow

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 38 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: females ages 38 or younger retrieval of at least 5 mature oocytes and fresh ejaculate samples Exclusion Criteria: frozen embryos surgically extracted sperm preparations embryo-biopsy cycles

Locations (1)

Meir Medical Center

Kfar Saba, Israel

Outcomes

Primary Outcomes

Pregnancy and delivery rates

Time frame: Within up to 10 month from treatment

Data from ClinicalTrials.gov

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