This is a multicenter prospective observational study lead by the FIL on sarcopenia and sGA as possible predictors of efficacy and toxicity outcomes in patients undergoing CAR-T cells treatment.
Study Type
OBSERVATIONAL
Enrollment
130
Patients will be treated with CAR-T cell product as per routine clinical practice.
Best Overall Response Rates (ORR)
Best Overall Response Rates (ORR) after CAR-T therapy according to the presence or absence of sarcopenic status
Time frame: up to 28 months
Best Complete Remission Rates (CRR)
Best Complete Remission Rates (CRR) after CAR-T therapy
Time frame: up to 28 months
Progression-Free Survival (PFS)
Progression-Free Survival (PFS) at + 12 months after CAR-T therapy
Time frame: up to 28 months
Overall Survival (OS)
Overall Survival (OS) at + 12 months after CAR-T therapy
Time frame: up to 28 months
Incidence of CAR-T related toxicities
Incidence of CAR-T related toxicities (specifically: CRS, ICANS, cytopenias) in the different sarcopenic subgroups and, for patients ≥65 years old, according to their functional status
Time frame: up to 28 months
Rate of admission to Intensive Care Units (ICU)
Rate of admission to Intensive Care Units (ICU) according to patients' sarcopenic and functional status
Time frame: up to 28 months
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