Neurally Adjusted Ventilatory Assist for Weaning From Invasive Mechanical Ventilation in Critically Ill Children

Chulalongkorn University60 enrolled

Overview

The goal of this clinical trial is to compare weaning from mechanical ventilation in critically ill children. The main questions it aims to answer are: * Will weaning with neurally adjusted ventilatory assist (NAVA) mode ventilation result in shorter ventilator day than synchronised intermittent mandatory ventilation (SIMV) mode? * Will weaning with NAVA mode ventilation result in shorter paediatric intensive care unit (PICU) length of stay than SIMV mode? Participants will be randomised to NAVA or SIMV group for weaning from mechanical ventilation, then PICU outcomes from both groups will be collected, analysed and compared.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

NONE

Enrollment

Conditions

Mechanical Ventilator Weaning Critically Ill Mechanical Ventilation Neurally Adjusted Ventilatory Assist

Interventions

NAVAPROCEDURE

weaning from mechanical ventilator using neurally adjusted ventilatory assist

Eligibility

Sex: ALLMin age: 1 MonthMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * all critically ill children admitted to PICU Exclusion Criteria: * failure to obtain informed consent

Locations (1)

Chulalongkorn University

Bangkok, Thailand

Outcomes

Primary Outcomes

ventilator day

number of days patients receive mechanical ventilation

Time frame: immediately after extubation

PICU length of stay

number of days patients remain in PICU

Time frame: immediately after PICU discharge

Secondary Outcomes

asynchrony index

asynchronous breaths divided by total breaths in 20 minutes

Time frame: 20-minute period randomly captured from the day of extubation

Data from ClinicalTrials.gov

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