Effects of Static Apnea at Low Lung Volume on Hypoalgesia, Cardiovascular Function and Respiratory Function

Centro Universitario La Salle60 enrolled

Overview

The aim of this randomized controlled study is to explore the hypoalgesic response of a 6 minutes of intermittent static apneas training session at low lung volume in healthy subjects; also, as secondary objectives, to analyze the cardiovascular and respiratory response produced during the intervention

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain Hypoxia Hypercapnia Apnea

Interventions

Voluntary apnoeaOTHER

Series of static apneas at low lung volume with a density of 30 seconds, followed by a normal breath of 10 seconds until completing the 6 minutes.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: \- Asymptomatic subjects aged between 18 and 64 years. Exclusion Criteria: * Cardiovascular, respiratory, metabolic, neurological or osteomuscular signs or pathologies. * History of epilepsy. * Pregnant * Pharmacological treatment. * Participants who present any type of pain on the day of the measurements or who have frequently suffered pain during the previous 4 weeks.

Locations (1)

CSEU LaSalle

Madrid, Spain

RECRUITING

Outcomes

Primary Outcomes

Pain pressure threshold (PPT) on thumb, anterior tibial and spinous process of C7

PPT is tested on the dorsal base of the distal phalanx of the thumb on the dominant side and on the muscle belly of the tibialis anterior on the dominant side. The region to be pressed is marked with a pen. The patient is instructed to report with the first appearance of the sensation of "discomfort". An ascending ramp of 0.5 kg/cm/s is applied, at the rhythm of a metronome. The measurement is started on the thumb and alternated with tibia and C7 until 3 measurements of each region are obtained, enough time to give 30 seconds of rest between measurements in the same region. This protocol has demonstrated high inter-observer reliability measuring healthy subjects (ICC = 0.91).

Time frame: before and after intervention (up 30 minutes)

Secondary Outcomes

Perceived Stress Scale (PSS)

14-item questionnaire about their thoughts and feelings in the last month. he scale has a range of scores from 0 to 56. The lower the score, the more favorable for the patient's health.

Time frame: before intervention (up 5 minutes)

Pittsburg Sleep Quality Index (PSQI)

9-item questionnaire on sleep quality in the past month. The scale has a range of scores from 0 to 21. The lower the score, the more favorable for the patient's health.

Time frame: before intervention (up 5 minutes)

Global Physical Activity Questionnaire (GPAQ)

6-item questionnaire on the level of physical activity at work, for commuting and in leisure time. A higher score means higher weekly physical activity

Time frame: before intervention (up 5 minutes)

Heart rate

Heart rate will be measured during the procedure by finger pulse oximetry.

Time frame: during intervention (up 6 minutes)

Data from ClinicalTrials.gov

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