A Study of Surufatinib as Adjuvant Therapy for Pancreatic Neuroendocrine Tumors

Inclusion Criteria: * pNETs lesions pathologically classified as WHO grade 1/ 2/ 3; * G2/3-NET with at least one high-risk postoperative recurrence factor, including but not limited to lymph node metastasis, neurovascular invasion, pancreatic duct dilation, tumor \>4cm, positive resection margin, etc.; or G1-NET with lymph node or remote transfer; * Complete surgical resection (R0 or R1 was achieved) ; * Adjuvant treatment was performed within 6-12 weeks after surgery; * Have received whole-body 68Ga PET-CT examination within the past six months; Exclusion Criteria: * Urinalysis shows urine protein ≥ 2+ and 24-hour protein quantity test shows urinary protein ≥1 g; * Under anti-hypertension treatment, still uncontrolled hypertension, defined as: systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 100 mmHg; * Clinically significant cardiovascular disease, including but not limited to, acute myocardial infarction within 6 months prior to enrollment, severe/unstable angina pectoris or coronary artery bypass grafting, congestive heart failure according to the New York Heart Association (NYHA) classification ≥ 2; ventricular arrhythmias which needs drug treatment; LVEF (LVEF) \<50%;