Effect of Acupoint Stimulation on Postoperative Delirium and Electroencephalogram

N/ANot Yet RecruitingNCT06161662

Zhihong LU226 enrolled

Overview

Transcutaneous electrical acupoint stimulation (TEAS) was reported to benefit the patients undergoing surgeries by reducing anesthetics consumption and decreasing anesthesia related adverse effects. Electroencephalogram (EEG) and EEG-related indicators are important indicators reflecting the conscious state of the brain, and different anesthetic drugs and anesthesia depths cause different EEG characteristic changes. The mechanism by which TEAS improves postoperative delirium (POD) is not clear, and whether changes in EEG characteristic parameters is involved needs to be further explored. Therefore, this study aims to observe the effect of TEAS at Neiguan and Shenmen acupoint on POD in elderly patients undergoing abdominal surgery, and to explore the EEG related mechanism underlying TEAS improving POD.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

226

Conditions

Anesthesia Postoperative Delirium Electroencephalogram

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. aged 65 years or older 2. American Society of Anesthesiologists (ASA) classification≤ Grade III 3. Patients scheduled for elective abdominal surgery under general anesthesia 4. Informed consent Exclusion Criteria: 1. Patients with severe central nervous system injury or severe cerebrovascular disease 2. Patients with cognitive dysfunction assessed by Confusion Assessment Method before surgery 3. Patients unable to cooperate with studies, such as psychiatric disorders or difficulty in communication 4. Patients with severe hepatic and renal insufficiency 5. Patients with severe respiratory diseases 6. Patients with contraindication for transcutaneous electrical stimulation, such as implanted electrophysiological devices, skin infection and damage at acupuncture points 7. Anticipated duration of anesthesia shorter than 2 hours or postoperative hospital stay shorter than 3 days

Outcomes

Primary Outcomes

Incidence of delirium by 7 days after surgery

Delirium will be assessed by 3-minute Diagnostic Interview for Confusion Assessment Method

Time frame: from end of surgery to 7 days after surgery

Secondary Outcomes

maximal electroencephalogram (EEG) alpha band power reduction

Time frame: From anesthesia induction to the end of surgery

Maximal decrease of regional cerebral oxygen saturation

Time frame: From anesthesia induction to the end of surgery

EEG explosive suppression time

EEG burst suppression is defined as a burst-suppression ratio (BSR) ≥ 10%, more than 1 minute

Time frame: From anesthesia induction to the end of surgery

Incidence of major neurological complications

Coma, stroke, altered state of consciousness

Time frame: From end of surgery to discharge from hospital, at an average of 7 days

The Athens Insomnia Scale and Epworth somnolence Scale score by 1 day after surgery