Transcutaneous electrical acupoint stimulation (TEAS) was reported to benefit the patients undergoing surgeries by reducing anesthetics consumption and decreasing anesthesia related adverse effects. Electroencephalogram (EEG) and EEG-related indicators are important indicators reflecting the conscious state of the brain, and different anesthetic drugs and anesthesia depths cause different EEG characteristic changes. The mechanism by which TEAS improves postoperative delirium (POD) is not clear, and whether changes in EEG characteristic parameters is involved needs to be further explored. Therefore, this study aims to observe the effect of TEAS at Neiguan and Shenmen acupoint on POD in elderly patients undergoing abdominal surgery, and to explore the EEG related mechanism underlying TEAS improving POD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
226
Electrodes will be attached on the surface of acupoints and electrical stimulation will be given
Electrodes will be attached on the surface of acupoints but no stimulation will be given
the First Affiliated Hospital of the Air Force Military Medical University
Xi'an, Shaanxi, China
Incidence of delirium by 7 days after surgery
Delirium will be assessed by 3-minute Diagnostic Interview for Confusion Assessment Method
Time frame: from end of surgery to 7 days after surgery
electroencephalogram (EEG) alpha band power
Time frame: From anesthesia induction to the end of surgery
Maximal decrease of regional cerebral oxygen saturation
Time frame: From anesthesia induction to the end of surgery
Incidence of major complications
myocardial ischemia needing intervention, heart failure, respiratory failure, pneumonia, Coma, stroke, altered state of consciousness
Time frame: From end of surgery to discharge from hospital, at an average of 7 days
The numerical rating scale of sleep quality
The scale is from 0 to 10. 0 is the worst sleep quality, 10 is the best sleep quality
Time frame: From end of surgery to 1 day after surgery
The numerical rating scale of pain
The scale is from 0 to 10. 0 is no pain, 10 is the worst pain
Time frame: From end of surgery to 1 day after surgery
The numerical rating scale of sleep quality
The scale is from 0 to 10. 0 is the worst sleep quality, 10 is the best sleep quality
Time frame: From end of surgery to 3 days after surgery
The numerical rating scale of pain
The scale is from 0 to 10. 0 is no pain, 10 is the worst pain
Time frame: From end of surgery to 3 days after surgery
The Quality of Recovery-15 Score by 3 days after surgery
Time frame: From end of surgery to 3 days after surgery
Incidence of delirium by 1 day after surgery
Time frame: From end of surgery to 1 day after surgery
Incidence of delirium by 3 days after surgery
Time frame: From end of surgery to 3 days after surgery
opioid consumption for patient controlled analgesia
the consumption is converted to morphine equivalence
Time frame: From end of surgery to 1 day after surgery
number of attempts for patient controlled analgesia
number of patients pressing the bolus button of the patient controlled analgesia device, indicating that the patient feel pain
Time frame: From end of surgery to 1 day after surgery
total sleep time
Time frame: From end of surgery to 1 day after surgery
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