This is a phase I study to evaluate drug-drug interactions (DDIs) of JAB-21822 as a perpetrator combined with midazolam , rosuvastatin, and digoxin and to evaluate DDIs of JAB-21822 as a victim combined with itraconazole, rifampicin, and omeprazole in healthy subjects.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
66
JAB-21822 was administered orally
Itraconazole was administered orally
Omeprazole was administered orally
Beijing GoBroad Hospital
Beijing, Beijing Municipality, China
Observed maximum concentrations (Cmax )of JAB-21822
Time frame: approximately 10 days
Area under the concentration versus time curve from dose to the last quantifiable concentration (AUC0-t) of JAB-21822
Time frame: approximately 10 days
Area under the concentration versus time curve from dose to infinity (AUC0-∞) of JAB-21822
Time frame: approximately 10 days
Observed maximum concentrations (Cmax )of midazolam, rosuvastatin, and digoxin
Time frame: approximately 10 days
Area under the concentration versus time curve from dose to the last quantifiable concentration (AUC0-t) of midazolam, rosuvastatin, and digoxin
Time frame: approximately 10 days
Area under the concentration versus time curve from dose to infinity (AUC0-∞) of midazolam, rosuvastatin, and digoxin
Time frame: approximately 10 days
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Midazolam , Rosuvastatin calcium and digoxin was administered orally
Rifampicin was administered orally