Recombinant Zoster Vaccine in Young Adult Solid Organ Transplant Recipients

Inclusion Criteria: * 19 years of age or older and willing to provide written informed consent for the study participation. * Prior recipient of solid organ transplant more than one year prior to participation. * Stable immunosuppressive medication regimen for last 6 months prior to participation * Participant must have a working telephone number, email address or patient Electronic Health Record (EHR) portal access and be willing to be contacted for study follow-up by any of these means. * For participants of childbearing potential, use of effective pregnancy prevention till 2 months post last dose. Exclusion Criteria: * Active treatment with corticosteroids or other immunosuppressive agents for acute or chronic rejection. * More than 2 courses of treatment for acute rejection within last 2 years prior to study enrollment * History of anaphylaxis or other allergic reaction after receiving prior vaccinations or vaccine components * Receipt of any inactivated vaccine 8 days before/after dose #1, subunit vaccine 14 days before/after dose #1 and live, attenuated or mRNA vaccine 30 days before/after dose #1 * History of herpes zoster, primary varicella or VZV vaccination within past 1 year prior to study entry * Active pregnancy as defined by positive pregnancy test at the time of screening and prior to each dose of vaccine * Febrile illness with Temp ≥39°C and/or infection that require hospitalization or oral antibiotics/antivirals/antifungal/anti-parasite medication within 14 days prior to day 1. * Any condition that, in the opinion of the investigator, may interfere with optimal participation in the study