Growth factors are defined as small proteins that trigger a cellular response after binding to cell receptors; Tissue engineering is now clinically applicable in a commercially available system involving the use of recombinant human platelet-derived growth factor. The objective of this study is to evaluate clinical and radiographic parameters in bone defects treated with platelet-derived growth factor in combination with allograft. Our hypothesis: Defects treated with DFDBA and rhPDGF-BB have better clinically and radiographic results that the defects treated with DFDBA and saline solution.
The study will be performed in 30 periodontal defects of 2 and 3 walls. The experimental group will consist of DFDBA placement with rhPDGF-BB and control DFDBA with saline solution. The clinical parameters recorded were Probing deep (PD), clinical attachment level (CAL), recession depth, Index of bleeding and plaque at baseline and at six months. Our universe is patients with periodontitis attending at the clinical in Periodontics at the Autonomous University of Nuevo Leon (UANL) School of Dentistry.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
30
At this intervention the periodontal defect will be treated with allograft and rHPDGF-BB (GEM21)
This will be used as the control group
Posgrado de Periodoncia, Facultad de Odontología, Universidad Autónoma de Nuevo León
Monterrey, Nuevo León, Mexico
RECRUITINGProbing depth
The distance from free gingival margin to sulcus depth, ≥4 millimeters (mm)
Time frame: Initial and six months after surgery
Bleeding on probing
Method to asses gingival inflammation. Gingival health is defined as \< 10% bleeding sites
Time frame: Initial and six months after surgery
Gingival Recession
The distance from the soft tissue (gingiva or alveolar mucosa) margin to cemento-enamel junction, ≥1 millimeters (mm)
Time frame: Initial and six months after surgery
Clinical Attachment Level
The distance from the cemento-enamel junction to the tip of a periodontal probe during periodontal diagnostic probing, ≥2 mm (millimeters)
Time frame: Initial and six months after surgery
Gingival Phenotype
Gingival phenotype is determined by gingival thickness and keratinized tissue width. Probe visible: thin (≤1 mm). Probe not visible: thick (\>1mm).
Time frame: Initial and six months after surgery
Plaque control record
O'Leary index is used for assessing oral hygiene skills of the patient
Time frame: Initial and six months after surgery
Radiographic Measurements
Cemento-enamel junction (CEJ)-Defect Base (DB): The distance of the cementoenamel junction at the base of the defect. Cemento-enamel junction (CEJ)-Bone crest (BC): The distance of the cemento-enamel junction to the crest of bone. Cemento-enamel junction (CEJ)- Root apex (RA): The distance of the cemento-enamel junction to root apex. Lineal Bone Growth (LBG) = CEJ to base of defect at baseline - CEJ to base of defect at 6 months. %BF: Percent bone fill was calculated by dividing LBG by the depth of the original bone defect
Time frame: Initial and six months after surgery
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