Retrospective analysis of specific characteristics of complications and long-term oncological and function outcomes in lower-limb osteosarcoma pediatric patients.
Clinical and functional outcomes were compared based on age groups, surgical methods, type of prosthesis, and primary tumor location. Patients were divided into the Low-age group (≤10 years old) and the High-age group (\>10 years old). Overall Survival rate (OS), Progression-Free Survival rate (PFS), and prosthesis survival rate were assessed using Kaplan-Meier curves, and non-parametric survival analysis (log-rank test) was used for comparison. The incidence of complications, local relapse rate (LRR), metastasis rate, final limb-salvage and amputation rate, and Musculoskeletal Tumor Society (MSTS) score of different independent groups were further evaluated using χ2 test or Fisher's exact test, and t-test was employed to evaluate the measurement data.
Study Type
OBSERVATIONAL
Enrollment
345
Retrospective analysis
Changye Zou
Guangzhou, Guangdong, China
Overall Survival rate (OS)
Oncological outcomes
Time frame: 2000-2019
Progression-Free Survival rate (PFS)
Oncological outcomes
Time frame: 2000-2019
Local recurrence rate(LRR)
Oncological outcomes
Time frame: 2000-2019
Metastasis rate
Oncological outcomes
Time frame: 2000-2019
Final limb-salvage and amputation rate
Oncological outcomes
Time frame: 2000-2019
Prosthesis survival rate
Functional outcomes
Time frame: 2000-2019
Musculoskeletal Tumor Society (MSTS) score
Functional outcomes
Time frame: 2000-2019
Complications
Functional outcomes
Time frame: 2000-2019
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