Influence of Cardiorespiratory Fitness and Body Composition on Resting and Post-exercise Indices of Vascular Health in Young Adults

Towson University43 enrolled

Overview

This research is being done to determine whether acute exercise causes differences in numbers of novel blood factors associated with vascular health in college-aged adults across different physical activity habits. As only \~50% of cardiovascular (CV) events can be explained by traditional CV risk factors such as high blood pressure and high cholesterol, it is anticipated that this research will provide a more comprehensive look into novel risk factors that may better explain CV risk and that may be modifiable through regular physical activity.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Endothelial Dysfunction Arterial Stiffness

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 29 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-29 years of age; healthy male and female; Physically inactive, defined as participation in less than 20 min of continuous endurance exercise on fewer than 2 days/week; Recreationally active, defined as participation in 30 min/day of moderate-intensity cardiovascular activity on greater than 4 days/week; Highly active- defined as performing 30-60 min of moderate- to vigorous-intensity endurance exercise greater than 5 days/week. Exclusion Criteria: * currently pregnant, previously diagnosed coronary heart disease or congenital heart disease, serum total cholesterol \>200 mg/dl, low-density lipoprotein cholesterol \>130 mg/dl, high-density lipoprotein cholesterol \< 35 mg/dl, fasting glucose \>100 mg/dl, systolic blood pressure \> 130 mmHg, diastolic blood pressure \>90 mmHg, and BMI \>30 kg/m2.

Outcomes

Primary Outcomes

endothelial function

flow-mediated dilation

Time frame: Baseline and 60 min post-exercise

arterial stiffness

augmentation index