This observational study aims to compare the prevalence of acquired abnormalities of the uterus (fibroids, polyps, intrauterine adhesions, adenomyosis) in women who have recurrent miscarriages with the fertile population.
High-quality studies including several meta-analyses have proven the association between congenital uterine anomalies and recurrent miscarriages. Nevertheless, there are limited studies evaluating the impact of acquired uterine anomalies on recurrent miscarriages. This prospective observational study will aim to compare the prevalence of acquired uterine anomalies between the study group and the control group. The secondary aim will be to compare the Endometrial morphological features like endometrial volume, endometrial and sub-endometrial vascularity between the two groups
Study Type
OBSERVATIONAL
Enrollment
400
The study group and the control group will be offered a 3D ultrasound scan as a part of this trial.
Prevalence of Acquired Uterine Anomalies
Primary outcome will be to compare the prevalence of acquired uterine anomalies (estimated as the proportion of anomalies diagnosed on 3D pelvic ultrasound) between study group and control group
Time frame: 24 months
Endometrial thickness
measured by ultrasound (in mm)
Time frame: 24 months
Endometrial volume
measured by 3D ultrasound (in ml)
Time frame: 24 months
Endometrial blood flow indices (vascularisation index, flow index and vascularisation flow index)
All three indices as measured by 3D ultrasound using VOCAL software
Time frame: 24 months
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